Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 GeneticVariation LHGDN Although coding SNP (rs2230808) was confirmed to have a significant association with AD, prediction of the effects of an amino acid substitution SNP rs2230808 (R1587K) on the three-dimensional structure and function of the ABCA1 protein using PolyPhen program revealed that it is unlikely to be functionally significant. 17510949

2007
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 GeneticVariation LHGDN In the present study, we examined the role of two ABCA1 polymorphisms, R219K (rs2230806) and G-17C (rs2740483) in modifying the risk of late-onset AD (LOAD) in a large American white cohort of 992 AD cases and 699 controls. 16725228

2007
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 GeneticVariation LHGDN Results indicate that variants of ABCA1 may affect the risk of AD, providing further support for a genetic link between AD and cholesterol metabolism. 15024730

2004
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 Biomarker LHGDN We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis. 12600718

2003