DisGeNET - a database of gene-disease associations

Source: LHGDN

Disease: Atherosclerosis ×

Gene: IGF1R ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	3480
Gene Symbol:	IGF1R

IGF1R

CUI:	C0004153
Disease:	Atherosclerosis

Atherosclerosis

0.050

Biomarker

LHGDN

Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.

18458087

2008

Entrez Id:	3480
Gene Symbol:	IGF1R

IGF1R

CUI:	C0004153
Disease:	Atherosclerosis

Atherosclerosis

0.050

AlteredExpression

LHGDN

Thus, TRAIL may play an important role in atherosclerosis by regulating IGF1R expression in VSMC in an NF-kappaB-dependent manner.

18178561

2008