Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET This work provides support for a model in which CRHR1 gene variation modulates the risk of problem drinking via an internalizing/negative affect pathway involving rVLPFC and reappraisal of negative emotion. 24623788

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence. 23294766

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence. 23220399

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET This study extends the literature on the interplay between CRHR1 variation and alcoholism, in the context of exposure to traumatic stress. 23473364

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET The goals of this commentary are to discuss the important contributions of the work by Kaur and colleagues titled Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice, published in this issue of Alcoholism: Clinical and Experimental Research, and to highlight the importance of preclinical research aimed at identifying the neurobiology of binge ethanol drinking. 22283808

2012