Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3360
Gene Symbol: HTR4
HTR4
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.330 Biomarker PSYGENET Our data suggest that the 5-HT4 receptor is involved in the neurobiological mechanism underlying familial risk for depression, and that lower striatal 5-HT4 receptor binding is associated with increased risk for developing MDD. 25522384

2014
Entrez Id: 3360
Gene Symbol: HTR4
HTR4
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.330 Biomarker PSYGENET This study investigated differences in 5-HT(4) receptor and 5-HT transporter (5-HTT) binding by quantitative autoradiography of [(3)H]SB207145 and (S)-[N-methyl-(3)H]citalopram in two murine models of depression-related states, olfactory bulbectomy and glucocorticoid receptor heterozygous (GR(+/-)) mice. 20060867

2010
Entrez Id: 3360
Gene Symbol: HTR4
HTR4
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.330 Biomarker PSYGENET Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. 20962330

2010
Entrez Id: 3360
Gene Symbol: HTR4
HTR4
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.330 Biomarker PSYGENET Thus, the 5-HT(4) receptor binding was decreased in the Flinders Sensitive Line depression model and in response to chronic paroxetine administration. 19476548

2009