Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker PSYGENET An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406. 22247094

2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker PSYGENET Norepinephrine and serotonin transporter genes: impact on treatment response in depression. 20588071

2010
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker PSYGENET Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). 18050262

2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker PSYGENET Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433

2003
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker PSYGENET According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087

1998