×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
99mTc-MIBI SPECT is noninvasive, and useful in predicting the presence of MDR1 gene-encoded Pgp in patients with hepatocellular carcinoma .
15112342 2004
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
P-glycoprotein or membrane pump induced drug efflux and altered prosurvival Bcl-2 expression are key mechanisms for drug resistance leading to failure of chemotherapy in HCC .29208281 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
GeneticVariation
BEFREE
MDR1 gene polymorphism correlated with pathological characteristics and prognosis in patients with primary hepatocellular carcinoma receiving interventional therapy.30779721 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
MDR1 was also overexpressed in cirrhotic non-tumorous liver tissues of some patients with HCC .8409332 1993
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
A MDR 1 HCC cell line Bel-7402/R was established.
15948236 2005
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.
21371443 2011
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
All of these results indicate that Baicalein can reverse P-gp -mediated MDR in HCC and may thus be useful for the treatment of drug-resistant HCC .
29571250 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
Although up-regulated in most HCC , Notch1 (unlike Notch3) did not contribute to the doxorubicin resistance of HCC lines.
19304334 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
As with Bmi-1, high ABCB1 expression was also observed in the early and well differentiated HCC .
20085590 2010
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
GeneticVariation
BEFREE
Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population.
25177961 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma .
28825695 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
BCT and TNF-alpha can reverse HCC MDR in nude mouse MDR1 model of liver neoplasm.
16237754 2005
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line.
20858479 2010
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma .
29299129 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Co-overexpression of the cMOAT and MDR1 genes was observed in 7 of 9 HCC and HB cell lines, but in none of the 10 other cancer cell lines.
10427140 1999
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
Connexin 32 affects doxorubicin resistance in hepatocellular carcinoma cells mediated by Src/FAK signaling pathway.
28968929 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
Consequently, P-gp will play an important role in the disposition of cinobufotalin <i>in vivo</i>, which provided a new combination therapy for the clinical treatment of HCC .
31156437 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
GeneticVariation
BEFREE
Correlation between clinical response to sorafenib in hepatocellular carcinoma treatment and polymorphisms of P-glycoprotein (ABCB1 ) and of breast cancer resistance protein (ABCG2): monocentric study.
28289864 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells.
16996216 2006
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Down-regulation of extracellular signal-regulated kinase 1/2 activity in P-glycoprotein -mediated multidrug resistant hepatocellular carcinoma cells.
19322916 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
GeneticVariation
BEFREE
Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma .
23109454 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Expression of P-glycoprotein in HCC s is associated with a shorter disease-free interval and shorter survival time.
8763260 1996
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Expression of multiple drug resistant (MDR) phenotype and over-expression of P-glycoprotein (P-gp ) in the human hepatocellular carcinoma (HCC ) cell clone P1(0.5), derived from the PLC/PRF/5 cell line (P5), are associated with strong resistance to oxidative stress and a significant (p < 0.01) increase in intracellular vitamin E content as compared with the parental cell line.
15453640 2004
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
AlteredExpression
BEFREE
Expression of P-gps (multidrug export pump MDR1 (ABCB1 ), phospholipid flippase MDR3 (ABCB4), sister of P-glycoprotein SPGP (ABCB11)) and basolateral MRP homologue MRP3 (ABCC3) showed a trend for decreased levels in HCC but was highly variable among individual tumors.
15780063 2005
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Liver carcinoma
0.600
Biomarker
BEFREE
Finally, we identified four key genes (CXCR4, ADH1C, ABCB1 and ADH1A) are associated with liver carcinoma and further cross-validated with Liverome, Protein Atlas database and bibliography.
27777109 2017