Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis. 22058001

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of VEGF and KDR single nucleotide polymorphisms with colorectal cancer susceptibility in Koreans. 23169005

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Overall, while the genetic variations in the VEGF and MMP genes are attractive candidates as prognostic markers, our study showed no evidence of associations of a large set of SNPs in these genes and overall survival of colorectal cancer patients in our study. 27334288

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association between EGF, TGF-beta1, VEGF gene polymorphism and colorectal cancer. 19011936

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. 31757048

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Vascular endothelial growth factor (VEGF) gene polymorphisms and colorectal cancer: a meta-analysis of epidemiologic studies. 23005896

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. 21743435

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Clinical implications of genetic variations in the VEGF system in relation to colorectal cancer. 22118052

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The aim of this study was to investigate the association between the risk for colorectal cancer and single nucleotide polymorphisms (SNP) of matrix metalloproteinase-2 (MMP2) -1306C/T, vascular endothelial growth factor (VEGF) 936C/T and hypoxia inducible factor-1α (HIF1A) 1772C/T. 21378341

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Prognostic significance of vascular endothelial growth factor gene polymorphisms in patients with colorectal cancer. 23132736

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Interplay between 3'-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans. 25423914

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of vascular endothelial growth factor gene polymorphisms with susceptibility and clinicopathologic characteristics of colorectal cancer. 18583877

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab. 31402291

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE VEGF gene polymorphisms and susceptibility to colorectal cancer. 25635747

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association between Polymorphisms in Vascular Endothelial Growth Factor Gene and Response to Chemotherapies in Colorectal Cancer: A Meta-Analysis. 25955730

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Furthermore, the subgroup analysis of recessive model indicates that VEGF +405G/C polymorphisms increase the risk for colorectal cancer. 24474253

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The present study suggests that the VEGF gene polymorphisms may play a role in the development of colorectal cancer. 18830612

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Our meta-analysis indicated that VEGF -2578C/A polymorphism was associated with the risk of colorectal cancer under homozygote comparison (OR=0.70, 95% CI=0.53-0.92), dominant model (OR=0.72, 95% CI=0.57-0.92), and recessive model (OR=0.82, 95% CI=0.67-1.01), although no evidence of association between VEGF -2578C/A polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR=0.97, 95% CI=0.81-1.16). 20635170

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Vascular endothelial growth factor gene polymorphisms in patients with colorectal cancer. 20187681

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer. 28328959

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The importance of -460 C/T and +405 G/C single nucleotide polymorphisms to the function of vascular endothelial growth factor A in colorectal cancer. 19904558

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE VEGF isoforms and mutations in human colorectal cancer. 12209585

2002

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We analyzed VEGF (-2578C>A, -1498C>T, -1154G>A, -634C>G, +936C>T) and eNOS (+894G>T, -786T>C, VNTR (variable number of tandem repeats) 27bp intron 4) polymorphisms by direct sequencing or Real Time PCR in 237 patients with advanced colorectal cancer. 25079441

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer. 27943279

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer. 18172253

2008