Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0001122
Disease: Acidosis
Acidosis 		0.300 Biomarker CTD_human NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. 29618784

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Biomarker CTD_human Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury. 24958931

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker CTD_human Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury. 24958931

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.300 Therapeutic CTD_human Mifepristone-inducible recombinant adenovirus attenuates paraquat-induced lung injury in rats. 24812154

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug 		0.300 Therapeutic CTD_human Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. 20605904

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4721507
Disease: Alveolitis, Fibrosing
Alveolitis, Fibrosing 		0.300 Biomarker CTD_human Suppression of nuclear factor erythroid 2-related factor 2 via extracellular signal-regulated kinase contributes to bleomycin-induced oxidative stress and fibrogenesis. 23570914

2013
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.400 Biomarker CTD_human Genetic knockout of NRF2 demonstrates its role in developmentally regulated γ-globin gene expression and the ability to control oxidative stress and the phenotypic severity of SCD. 29255069

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.400 Biomarker CTD_human The carcinogenesis of prostate cancer (PCa) in TRAMP model is highly correlated with hypermethylation in the promoter region of Nrf2 and the accompanying reduced transcription of Nrf2 and its regulated detoxifying genes. 29228771

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0887833
Disease: Carcinoma, Pancreatic Ductal
Carcinoma, Pancreatic Ductal 		0.300 Biomarker CTD_human Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. 21489257

2011
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424

2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062

2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860

2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062

2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860

2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424

2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1565321
Disease: Cholera Infantum
Cholera Infantum 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.350 Therapeutic CTD_human Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice. 20977460

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0005398
Disease: Cholestasis, Extrahepatic
Cholestasis, Extrahepatic 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0376628
Disease: Chromosome Breakage
Chromosome Breakage 		0.300 Therapeutic CTD_human Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. 27774770

2017