Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0001122
Disease: Acidosis
Acidosis 		0.300 Biomarker CTD_human NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. 29618784

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0005398
Disease: Cholestasis, Extrahepatic
Cholestasis, Extrahepatic 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0007166
Disease: Low Cardiac Output
Low Cardiac Output 		0.300 Biomarker CTD_human Nrf2 expression and function, but not MT expression, is indispensable for sulforaphane-mediated protection against intermittent hypoxia-induced cardiomyopathy in mice. 30096613

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0019209
Disease: Hepatomegaly
Hepatomegaly 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0038002
Disease: Splenomegaly
Splenomegaly 		0.300 Biomarker CTD_human Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model. 29255069

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0220981
Disease: Metabolic acidosis
Metabolic acidosis 		0.300 Biomarker CTD_human We conclude that NRF2 is required to adapt the levels of SNAT3 in response to metabolic acidosis. 29618784

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0238065
Disease: Secondary Biliary Cholangitis
Secondary Biliary Cholangitis 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0242698
Disease: Ventricular Dysfunction, Left
Ventricular Dysfunction, Left 		0.300 Therapeutic CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0600177
Disease: Low Cardiac Output Syndrome
Low Cardiac Output Syndrome 		0.300 Biomarker CTD_human Nrf2 expression and function, but not MT expression, is indispensable for sulforaphane-mediated protection against intermittent hypoxia-induced cardiomyopathy in mice. 30096613

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0600519
Disease: Ventricular Remodeling
Ventricular Remodeling 		0.300 Therapeutic CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0600520
Disease: Left Ventricle Remodeling
Left Ventricle Remodeling 		0.300 Therapeutic CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1306571
Disease: Hepatic Insufficiency
Hepatic Insufficiency 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C2718076
Disease: Fetal Mummification
Fetal Mummification 		0.300 Biomarker CTD_human Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model. 29255069

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1 		0.300 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Therapeutic CTD_human Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction. 28373008

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Therapeutic CTD_human Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction. 28373008

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0333704
Disease: Chromosome Breaks
Chromosome Breaks 		0.300 Therapeutic CTD_human Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. 27774770

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0376628
Disease: Chromosome Breakage
Chromosome Breakage 		0.300 Therapeutic CTD_human Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. 27774770

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1449861
Disease: Micronuclei, Chromosome-Defective
Micronuclei, Chromosome-Defective 		0.300 Therapeutic CTD_human Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. 27774770

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1449862
Disease: Micronuclei, Genotoxicant-Induced
Micronuclei, Genotoxicant-Induced 		0.300 Therapeutic CTD_human Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. 27774770

2017