×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
1338904
1992
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
APC mutations occur early during colorectal tumorigenesis.
1528264
1992
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
[The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants].
2281069
1990
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
8187091
1994
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
8898652
1996
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
9679244
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
10479724
1999
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
"APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."
10737795
2000
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Transcriptional control by the TGF-beta/Smad signaling system.
10775259
2000
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Mutations of the BRAF gene in human cancer.
12068308
2002
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Mutations of the APC gene in human sporadic colorectal cancers.
12374230
2002
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Role of Smad4 (DPC4) inactivation in human cancer.
12821112
2003
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
14715079
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
High frequency of mutations of the PIK3CA gene in human cancers.
15016963
2004
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
High frequency of mutations of the PIK3CA gene in human cancers.
15016963
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
GeneticVariation
CLINVAR
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
15930273
2005
×
Entrez Id:
208
Gene Symbol:
AKT2
AKT2
Colorectal Neoplasms
0.300
GeneticVariation
CLINVAR
Colorectal cancer: mutations in a signalling pathway.
16094359
2005
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
Colorectal Neoplasms
0.410
CausalMutation
CLINVAR
BRAF mutation predicts sensitivity to MEK inhibition.
16273091
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
16361624
2005
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
Colorectal Neoplasms
0.200
GeneticVariation
CLINVAR
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
16478791
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
16618717
2006