×
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
Colorectal Neoplasms
0.410
CausalMutation
CLINVAR
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models.
17699718 2007
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
17704924 2008
×
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.
17994767 2007
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
18186519 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
18316791 2008
×
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
Colorectal Neoplasms
0.190
GeneticVariation
CLINVAR
Germline EPHB2 receptor variants in familial colorectal cancer.
18682749 2008
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974 2008
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974 2008
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer.
18992635 2008
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.
19001320 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.
19114683 2009
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.
19223544 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
19363522 2009
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
GeneticVariation
CLINVAR
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.
19366826 2009
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.
19366826 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.
19366826 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Clinical biomarkers in oncology: focus on colorectal cancer.
19537845 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.
19679400 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
19794125 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
19881948 2009
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
PIK3CA mutations predict local recurrences in rectal cancer patients.
19903786 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
PIK3CA mutations predict local recurrences in rectal cancer patients.
19903786 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
20350999 2010
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.
20413299 2010
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058 2010