Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.700 GeneticVariation UNIPROT Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.700 GeneticVariation UNIPROT An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis. 28073828

2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 GeneticVariation UNIPROT Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. 17676033

2007
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 GeneticVariation UNIPROT Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort. 26293184

2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 GeneticVariation UNIPROT Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease. 23342295

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 GeneticVariation UNIPROT STAT3 mutations in the hyper-IgE syndrome. 17881745

2007
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C2936739
Disease: Hyper-Immunoglobulin E Syndrome, Autosomal Dominant
Hyper-Immunoglobulin E Syndrome, Autosomal Dominant 		0.800 Biomarker CTD_human Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C3887645
Disease: Job Syndrome
Job Syndrome 		0.800 Biomarker CTD_human These findings emphasize the critical role of STAT3 in autoimmune disease and contrast with the germline inactivating STAT3 mutations that result in hyper IgE syndrome. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C3887645
Disease: Job Syndrome
Job Syndrome 		0.800 Biomarker GENOMICS_ENGLAND

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.700 Biomarker CTD_human Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.700 Biomarker GENOMICS_ENGLAND Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.700 Biomarker CTD_human

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.700 Biomarker GENOMICS_ENGLAND Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. 25359994

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 Biomarker GENOMICS_ENGLAND Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. 25359994

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 Biomarker GENOMICS_ENGLAND Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. 20159255

2010
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4721531
Disease: HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT 		0.630 Biomarker GENOMICS_ENGLAND Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1968689
Disease: Hyper-Immunoglobulin E Syndrome, Autosomal Recessive
Hyper-Immunoglobulin E Syndrome, Autosomal Recessive 		0.550 Biomarker CTD_human Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. 25038750

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.500 Biomarker CTD_human Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 20228799

2010
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.500 Biomarker CTD_human Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405

2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 Biomarker GENOMICS_ENGLAND

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C3489795
Disease: Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant
Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant 		0.500 Biomarker CTD_human

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0015967
Disease: Fever
Fever 		0.410 Biomarker CTD_human Furthermore, deletion of STAT3 in the brain endothelium also resulted in attenuated fever. 25429137

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker CTD_human MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. 19028472

2009
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker CTD_human STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts. 26432044

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.400 Biomarker CTD_human Our results suggested that pravastatin's aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity. 19330073

2008