Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5329
Gene Symbol: PLAUR
PLAUR
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.500 Biomarker CTD_human Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells. 22261521

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. 23867902

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. 21187089

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. 22503731

2012

Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Therapeutic CTD_human Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. 1318976

1992

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation. 19617202

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. 19700239

2010

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. 22580338

2012

Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Resveratrol represses YKL-40 expression in human glioma U87 cells. 21029458

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells. 24333868

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.310 Biomarker CTD_human Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. 20188714

2010

Entrez Id: 406933
Gene Symbol: MIR141
MIR141
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Therapeutic CTD_human Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila. 27616325

2016

Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion. 23289900

2013

Entrez Id: 8518
Gene Symbol: ELP1
ELP1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. 27811057

2016

Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Therapeutic CTD_human Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. 17130448

2006

Entrez Id: 813
Gene Symbol: CALU
CALU
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. 15048980

2004

Entrez Id: 2056
Gene Symbol: EPO
EPO
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Erythropoietin in thyroid cancer. 16699298

2006

Entrez Id: 4830
Gene Symbol: NME1
NME1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. 15048980

2004

Entrez Id: 135932
Gene Symbol: TMEM139
TMEM139
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. 26213588

2015

Entrez Id: 6615
Gene Symbol: SNAI1
SNAI1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025

2013

Entrez Id: 91801
Gene Symbol: ALKBH8
ALKBH8
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. 27811057

2016

Entrez Id: 1748
Gene Symbol: DLX4
DLX4
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. 26213588

2015

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. 22580338

2012

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Erythropoietin in thyroid cancer. 16699298

2006

Entrez Id: 57181
Gene Symbol: SLC39A10
SLC39A10
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker CTD_human Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. 17359283

2007