Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker PSYGENET Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. 23849431

2013
Entrez Id: 27161
Gene Symbol: AGO2
AGO2
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker CTD_human Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. 20643829

2010
Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker PSYGENET ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 23635803

2013
Entrez Id: 23780
Gene Symbol: APOL2
APOL2
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker CTD_human Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. 17205118

2006
Entrez Id: 23237
Gene Symbol: ARC
ARC
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker CTD_human Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. 18311559

2008
Entrez Id: 374868
Gene Symbol: ATP9B
ATP9B
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker CTD_human Substance dependence low-density whole genome association study in two distinct American populations. 18438686

2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. 20971807

2011
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase. 25814464

2015
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. 22935511

2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. 23000451

2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. 22960160

2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. 18514640

2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction. 18292872

2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.340 Therapeutic CTD_human Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. 20060817

2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. 20711185

2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. 20810894

2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. 18311559

2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. 17618281

2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. 20810894

2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. 17651427

2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. 17651427

2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. 18311559

2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. 17618281

2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Therapeutic CTD_human A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. 19321768

2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. 20711185

2010