Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE <b>Purpose:</b> There is extensive cross-talk between VEGF- and EGFR-pathway signaling in colorectal cancer. 29490990

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 GeneticVariation BEFREE <i>BRAF</i><sup>V600E</sup> mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. 29483217

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Colorectal cancer is a multistep process affecting several signaling pathways including EGFR (epidermal growth factor receptor), a therapeutic target for metastatic disease. 28936923

2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE EGFR protein expression did not influence survival in this colorectal cancer patient cohort (P>or=0.05). 12441262

2002
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE EGFR mRNA and protein expression were detected by RT-PCR and immunoblotting in all 7 colorectal cancer cell lines studied. 14648715

2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. 16243822

2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Epidermal growth factor receptor analyses in colorectal cancer: a comparison of methods. 17016647

2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Epidermal growth factor receptor serum (sEGFR) level may predict response in patients with EGFR-positive advanced colorectal cancer treated with gefitinib? 18327586

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 GeneticVariation BEFREE Epidermal growth factor receptor (EGFR) status and K-Ras mutations in colorectal cancer. 18632722

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE EGFR, HER-2 and COX-2 levels in colorectal cancer. 19102009

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases. 19701635

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE EGFR expression variance in paired colorectal cancer primary and metastatic tumors. 20595818

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR and KRAS in colorectal cancer. 20857619

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR monoclonal antibodies have been shown to increase the median survival and are approved for the treatment of colorectal cancer. 21464950

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR promoter hypermethylation, after confirmation in larger data set, may represent a valuable asset in further studies investigating EGFR as a therapeutic target in colorectal cancer. 21559018

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer. 21694725

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 GeneticVariation BEFREE Epidermal growth factor receptor pathway mutations and colorectal cancer therapy. 21970483

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression BEFREE Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor (VEGF) are often overexpressed in colorectal cancer and are associated with inferior outcomes. 26364891

2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE Epidermal growth factor receptor (EGFR) and its ligands amphiregulin (AREG) and epiregulin (EREG) play a central role in the development of colorectal cancer, but the prognostic values of AREG and EREG are controversial. 27344184

2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR is mainly a predictive factor for the prognosis of post-operative patients with TNM stage I-II colorectal cancer, and nm23 is important for predicting the prognosis of patients with stage III-IV, and EGFR and nm23 could be as predictor of combination. 27888614

2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. 28400195

2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR-targeted micelles containing near-infrared dye for enhanced photothermal therapy in colorectal cancer. 28445743

2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer. 30096327

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer. 30156250

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker BEFREE EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer. 30478887

2019