Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis. 31740220

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study has revealed that BsmI and FokI polymorphisms of VDR gene significantly associated with an increased risk of PTB. 29727015

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study aims to investigate the association of vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms with susceptibility and severity to multidrug-resistant tuberculosis (MDR-TB) in comparison with drug-sensitive tuberculosis (DS-TB) and health controls in China.A total of 180 patients with pulmonary TB (128 DS-TB, 52 MDR-TB) and 59 healthy controls were enrolled into 3 groups. 30045341

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE NRAMP1 and VDR gene polymorphisms in susceptibility to pulmonary tuberculosis among Andhra Pradesh population in India: a case-control study. 28583097

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE In conclusion, VDR <i>Bsm</i>I polymorphism is not a risk factor for PTB in overall population. 28533426

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Heterozygous (TG) and mutants (GG) forms of Apa1 VDR SNPs were significantly associated with TBM compared to controls [TG; p = 0.001, OR = 2.86 (1.58-5.17), GG; p = 0.002, OR = 5.11 (1.80-14.54)] and pulmonary tuberculosis. 27207494

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The heterozygous and mutant variants of VDR ApaI gene were significantly more common in patients with spinal tuberculosis in comparison with patients with pulmonary tuberculosis (P < 0.001; OR 2.90 [1.65-5.10]) and controls (P < 0.001; OR 6.56 [3.41-12.61]). 27124026

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Regulatory role of Cdx-2 and Taq I polymorphism of vitamin D receptor gene on chemokine expression in pulmonary tuberculosis. 27067904

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Our findings demonstrated associations between VDR polymorphisms and PTB development. 27595605

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population. 26774366

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE To investigate natural-resistance-associated macrophage protein 1 (NRAMP1), mannose-binding lectin (MBL), vitamin D receptor (VDR) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. 26261060

2015

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This meta-analysis suggested that the VDR FokI polymorphism is associated with a susceptibility to PTB in East Asians. 26345844

2015

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Both vitamin D deficiency and genetic variants in the vitamin D receptor (VDR) have been reported to associate with delayed response to intensive-phase therapy for pulmonary tuberculosis. 26193879

2015

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE TLR2, TLR4, and VDR polymorphisms were previously associated with tuberculosis (TB) and were here investigated as candidates for pulmonary TB (PTB) susceptibility in a Moroccan population group. 24727508

2014

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE To assess the role of VDR and SLC11A1 gene polymorphisms in the development of pulmonary TB (PTB) in an ethnically matched population of India. 22008758

2011

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study was aimed to investigate the association between VDR gene polymorphisms and different clinical forms of pulmonary tuberculosis (TB) in different population groups. 21645645

2011

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE We undertook this study to investigate the association between FokI polymorphism in VDR gene and susceptibility to spinal TB in Chinese Han population. 20430254

2010

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study confirmed the association of SNPs in BsmI (B/b + b/b) of VDR and SNPs in -308A (G/A +G/G) of TNF-alpha genes with susceptibility to tuberculosis in Iranian PTB patients. 20231985

2009

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The influence of FokI, BsmI, ApaI and TaqI variants of VDR gene on 1, 25(OH)(2) D(3) modulated granzyme A expression of cytotoxic lymphocytes induced by culture filtrate antigen (CFA) of Mycobacterium tuberculosis was studied in 40 pulmonary tuberculosis (PTB) patients and 49 normal healthy subjects (NHS) by flow cytometry. 19014932

2009

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Relative quantification of mRNA using real-time PCR revealed increased VDR mRNA expression in live M. tuberculosis-stimulated culture in PTB patients (p < 0.01) than normal healthy subjects. 19219539

2009

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN We investigated the polymorphisms in the 5' regulatory region of VDR gene in 206 normal healthy subjects and 166 patients with pulmonary tuberculosis from south India. 18397302

2008

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE We investigated the polymorphisms in the 5' regulatory region of VDR gene in 206 normal healthy subjects and 166 patients with pulmonary tuberculosis from south India. 18397302

2008

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Regulatory role of promoter and 3' UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. 18231846

2008

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients. 17449323

2007

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome. 17611589

2007