×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
AlteredExpression
BEFREE
Furthermore, expression of CCR6 was found in infiltrating mononuclear cells in the cellular clusters and around the vessels of RA synovial tissue.
11472439 2001
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
BEFREE
The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis .
12948524 2003
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
BEFREE
Overall, these studies indicate that MIP-3alpha and CCR6 may function to recruit monocytes and memory lymphocytes from the RA PB to the RA joint.
12695561 2003
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
LHGDN
Immunohistochemical analysis for CCR6 , CCL20, and RANKL was performed on bone samples from RA patients.
17133360 2007
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
AlteredExpression
BEFREE
These results indicate that CCR6 expression contributes to Th17 cell function in autoimmune disease, especially in autoimmune arthritis such as RA .
18025126 2007
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
20453841 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
AlteredExpression
BEFREE
The CCR6DNP genotype was correlated with the expression level of CCR6 and was associated with the presence of interleukin-17 (IL-17) in the sera of subjects with rheumatoid arthritis .
20453841 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
CTD_human
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
20453841 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASCAT
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
20453841 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
CTD_human
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASCAT
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842 2010
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
AlteredExpression
BEFREE
RT-PCR of synovial extracts confirmed the predominance of CCL20/CCR6 mRNA expression in RA synovium.
21724701 2011
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASCAT
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596 2012
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596 2012
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
22446963 2012
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
CTD_human
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596 2012
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
BEFREE
We previously reported an analysis of single-nucleotide polymorphisms (SNPs) in 3 validated European rheumatoid arthritis (RA) susceptibility loci, TAGAP, TNFAIP3, and CCR6 , in African American patients with RA .
22127930 2012
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
BEFREE
Direct sequencing of DNA was performed to ascertain whether the functional dinucleotide polymorphism of CCR6 previously identified in RA (CCR6DNP) was also present in SSc.
23983073 2013
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
BEFREE
CCR6 has been associated with RA in genome-wide association studies and has been shown to be an interesting candidate for a therapeutic approach, considering its and CCL20's expression patterns within the tissue as well as the immune system.24394994 2014
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
24390342 2014
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASCAT
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
24390342 2014
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASDB
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
24782177 2014
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
GeneticVariation
GWASCAT
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
24782177 2014
×
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
Rheumatoid Arthritis
0.500
Biomarker
BEFREE
Moreover, current approaches to target CCR6 + Th cells and future directions of research to find specific CCR6 + Th cell targets in the treatment of patients with RA and other CCR6 + Th cell mediated autoimmune diseases are highlighted.
25828206 2015