×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Collectively, the results of the present study suggest that there were no significant associations of ABCB1 /MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models.
23504525 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Carriers of the variant allele of MDR1 intron 3 had odds ratios (95% CI) of 0.97 (0.72-1.29) for developing adenomas, and 0.70 (0.41-1.21) for colorectal cancer , respectively, compared to homozygous wild type carriers.
19250544 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1 ).
28667355 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1.
30439718 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells.
23608383 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
In the present study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy Bulgarian volunteers were evaluated for the two polymorphisms in MDR1 .
17674045 2008
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases.8898977 1996
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp ) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer .
24901713 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation.
30662808 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
A comprehensive investigation on common polymorphisms in the MDR1 /ABCB1 transporter gene and susceptibility to colorectal cancer .
22396794 2012
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
We aimed to investigate the effect of MDR1 polymorphisms on its expression level and related characteristics in Iranian colorectal cancer patients.
22394004 2011
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.31487863 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer : In vitro and in vivo study.
28302530 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.
30741544 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer .
29793178 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Effects of genetic polymorphisms of MDR1 , FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.
16800822 2006
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The purpose of this present study was to investigate the reversal effect of BU on ABCB1 -mediated multidrug resistance in colorectal cancer .
28624793 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
PubMed, Embase, Google Scholar, Cbmdisc and CNKI were searched for studies on the relationship of ABCB1 /MDR1 gene SNPs and the incidence of colorectal cancer .
23279665 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1 ) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.
19930591 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer .
19415305 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer .
27060927 2016
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.25355168 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Genotyping of SNPs in the ABCB1 gene prior to chemotherapy administration could help reduce adverse reactions in colorectal cancer patients.
21142915 2010
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer .19192650 2009
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer .
20127181 2011