×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Regulation of ATP-binding cassette subfamily B member 1 by Snail contributes to chemoresistance in colorectal cancer .
31774615 2020
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.31487863 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.
30741544 2019
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1.
30439718 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation.
30662808 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer .
29793178 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer .
30213564 2018
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1 ).
28667355 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer : In vitro and in vivo study.
28302530 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The purpose of this present study was to investigate the reversal effect of BU on ABCB1 -mediated multidrug resistance in colorectal cancer .
28624793 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.
29390571 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
We investigated the consequences of ABCB1 /MDR1 loss-of-function in a common murine model for CAC (AOM/DSS).
28686677 2017
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer .
27060927 2016
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The expression of cytochrome P450 2C19 (CYP2C19) and ATP-binding cassette, sub-family B member 1 (ABCB1 ) were significantly lower in the EREC group (6/15) compared to the NREC group (9/15) in colorectal cancer with metachronous liver metastasis and with serum CEA >5 ng/ml.
27127120 2016
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer .
25691056 2015
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp ) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer .
24901713 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.25355168 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
JJR reversed multidrug resistance and enhanced the sensitivity to chemotherapy, which could be attributed to the down-regulation of COX-2 in MDR1 /P-gp-mediated MDR colorectal cancer after chemotherapy.
23543356 2014
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Collectively, the results of the present study suggest that there were no significant associations of ABCB1 /MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models.
23504525 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells.
23608383 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
PubMed, Embase, Google Scholar, Cbmdisc and CNKI were searched for studies on the relationship of ABCB1 /MDR1 gene SNPs and the incidence of colorectal cancer .
23279665 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T).
23193993 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis.
23746184 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population.
23803084 2013
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
A comprehensive investigation on common polymorphisms in the MDR1 /ABCB1 transporter gene and susceptibility to colorectal cancer .
22396794 2012