DisGeNET - a database of gene-disease associations

Source: UNIPROT

Disease: PARKINSON DISEASE 8 (disorder) ×

Gene: LRRK2 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

15680456

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.

28720718

2017

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

23395371

2013

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Crystal structure of the WD40 domain dimer of LRRK2.

30635421

2019

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

16251215

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

21850687

2011

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

LRRK2 R1441G in Spanish patients with Parkinson's disease.

15925109

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

15880653

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease.

16333314

2006

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

A common LRRK2 mutation in idiopathic Parkinson's disease.

15680457

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

29212815

2018

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.

15680455

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Clinical features of LRRK2-associated Parkinson's disease in central Norway.

15852371

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

G2019S LRRK2 mutation in French and North African families with Parkinson's disease.

16240353

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.

22956510

2012

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Structural interface between LRRK2 and 14-3-3 protein.

28202711

2017

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

LRRK2 mutations in Parkinson disease.

16157908

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Lrrk2 pathogenic substitutions in Parkinson's disease.

16172858

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

16269541

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.

15732108

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

15541309

2004

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

LRRK2 mutations and Parkinsonism.

15811454

2005

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.

16250030

2006

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

The familial Parkinsonism gene LRRK2 regulates neurite process morphology.

17114044

2006

Entrez Id:	120892
Gene Symbol:	LRRK2

LRRK2

CUI:	C1846862
Disease:	PARKINSON DISEASE 8 (disorder)

PARKINSON DISEASE 8 (disorder)

0.930

GeneticVariation

UNIPROT

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.

16272164

2005