×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
HPO
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1 /2 mutation carriers because of their increased risk of ovarian carcinoma .
29315498
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Women with an existing breast carcinoma diagnosis who are found to carry a BRCA1 /2 mutation have a substantial risk of developing both a contralateral breast carcinoma and ovarian carcinoma .
11900216
2002
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
One mutation and three rare variants were identified in four women with no family history of breast or ovarian carcinoma whereas all women with affected first-degree relatives did not harbor BRCA1 mutations.
10951344
2000
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma .
9661879
1998
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
BRCA1 5382insC mutation in sporadic and familial breast and ovarian carcinoma in Scotland.
9155062
1997
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
It is not yet known how frequently somatic BRCA1 mutations predispose to breast and ovarian carcinoma in the general female population.
8173065
1993
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
28882436
2017
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
To compare BRCA1 mutations in papillary serous carcinoma of the peritoneum and papillary serous ovarian carcinoma .
9764635
1998
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma .
31653147
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma .
23339184
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma .
30446260
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Eligible patients are premenopausal BRCA1 /2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma .
26286255
2015
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
At the time of salpingo-oophorectomy, five of 58 BRCA1 carriers (8.6%) were diagnosed with an occult carcinoma: two fallopian tube carcinomas, two ovarian carcinomas and one case was defined as a fallopian tube/ovarian carcinoma .
15083174
2004
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
We propagated a novel BRCA1 -null human ovarian cancer cell line UWB1.289 from a tumor of papillary serous histology, the most common form of ovarian carcinoma .
17259345
2007
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 /2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma .
30606148
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
The similar frequency distribution of BRCA1 /2 mutations in PPC and OvC observed in the present study indicates that these mutations may predispose to PPC as well and that this neoplasm is part of the hereditary breast-ovarian cancer syndrome.
12504628
2003
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma .
10717622
2000
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma .
23232854
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
CausalMutation
CGI
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
A high proportion of young women with invasive OC have mutations in BRCA1 , and a smaller fraction have mutations in other known OC genes.
26718727
2016
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome.
11550149
2001
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.
10880552
2000
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Multiple mechanisms cause nearly universal dysfunction of BRCA1 and/or BRCA2 in hereditary and sporadic ovarian carcinoma .
12237285
2002
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Potent immunogenicity in BRCA1 -mutated patients with high-grade serous ovarian carcinoma .
29855141
2018