×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CGI
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
CLINVAR
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
12460919
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Although >90% of BRAF mutations in melanoma involve codon 599 (57 of 60), 8 of 9 BRAF mutations reported to date in NSCLC are non-V599 (89%; P < 10(-7)), strongly suggesting that BRAF mutations in NSCLC are qualitatively different from those in melanoma; thus, there may be therapeutic differences between lung cancer and melanoma in response to RAF inhibitors.
12460918
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
12460919
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
UNIPROT
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
12460919
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
BRAF and RAS mutations in human lung cancer and melanoma.
12460918
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Mutations of the BRAF gene in human cancer.
12068308
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Although a few Caucasian lung cancer patients harbored BRAF mutations, there have been no reports about the BRAF mutation in Japanese patients with lung cancer .
16376942
2006
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
These data, together with the nonoverlapping pattern of EGFR and BRAF mutations in human lung cancer , suggest that these lesions define distinct clinical entities whose treatment should be guided by prospective real-time genotyping.
19010912
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Genetic predictors of MEK dependence in non-small cell lung cancer.
19010912
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
19238210
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Consistent with earlier reports, our results show that KRAS and BRAF mutation frequencies in colorectal cancer were 44.3% and 13.0%, respectively, while EGFR mutations were detected in 11.1% of the lung cancer specimens.
21943394
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma.
21483012
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
The role of KRAS and BRAF mutations and ALK rearrangement in lung cancer -targeted therapy, are also reviewed.
21463141
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.
21483012
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.
22798288
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
22649091
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
22773810
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib.
22743296
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
GeneticVariation
BEFREE
In this study, using both novel and established technologies, we developed a clinically practical assay to survey the status of three frequently mutated genes in lung cancer (EGFR, K-ras and TP53) and two genes (BRAF and β-catenin) with known hotspot mutations in many other cancers.
22407457
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
22649091
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.
24035431
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Carcinoma of lung
0.700
CausalMutation
CLINVAR
Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer.
23524406
2013