IGHV1-12
Uterine Carcinosarcoma
0.010
Biomarker
BEFREE
Complex karyotypic aberrations, including i(12p ), in malignant mixed mullerian tumor of uterus .
1317254
1992
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
Uterine Carcinosarcoma
0.140
GeneticVariation
BEFREE
The current results suggest absence of ERBB-2 overexpression in uterine leiomyosarcoma, uterine adenosarcoma, and endometrial stromal sarcoma, whereas the ERBB-2 gene might have a biologic role in uterine carcinosarcoma and undifferentiated uterine sarcomas.
15581967
2004
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
Uterine Carcinosarcoma
0.140
AlteredExpression
BEFREE
We describe HER-2/neu overexpression and her-2/neu oncogene amplification in a case of uterine carcinosarcoma occurring in a 46-year-old women who had undergone mastectomy and a 2-year postoperative treatment with tamoxifen for invasive breast cancer.
15901136
2005
×
Entrez Id:
7516
Gene Symbol:
XRCC2
XRCC2
Uterine Carcinosarcoma
0.010
GeneticVariation
BEFREE
We sought to determine if XRCC2 mutation is important to uterine carcinosarcoma tumorigenesis and whether the XRCC2 poly-T tract is a target for mutation in cells lacking MMR.
16169065
2006
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
Uterine Carcinosarcoma
0.140
AlteredExpression
BEFREE
Demonstration of HER-2/neu overexpression and amplification in uterine carcinosarcoma may represent the first rationale step for further investigations.
16445668
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Uterine Carcinosarcoma
0.120
Biomarker
BEFREE
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis.
16810312
2006
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
Uterine Carcinosarcoma
0.010
GeneticVariation
BEFREE
TGF-beta signaling is activated in CS and chromosomal gains at 19q13, which includes the TGFB1 locus, suggest that this may contribute to high expression of TGF-beta and thereby EMT phenotype of CS .
22072501
2012
×
Entrez Id:
4087
Gene Symbol:
SMAD2
SMAD2
Uterine Carcinosarcoma
0.010
AlteredExpression
BEFREE
Immunohistochemistry showed that carcinomatous region of CS have higher expression of p-SMAD2 /3 than EC (P = 0.008).
22072501
2012
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
Uterine Carcinosarcoma
0.140
AlteredExpression
BEFREE
AKT, EGFR, C-ErbB-2 , and C-kit expression in uterine carcinosarcoma .
23896716
2013
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Uterine Carcinosarcoma
0.120
GeneticVariation
BEFREE
The expression of AKT, epithelial growth factor receptor, C-Kit, and C-ErbB-2 were studied by immunohistochemistry and exons 9 and 20 of PIK3CA gene were sequences in a cohort of 37 UCS , including 23 early-stage (I and II) and 14 late-stage (III and IV) tumors.
23896716
2013
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Uterine Carcinosarcoma
0.010
Biomarker
BEFREE
These results indicate that AKT pathway may be important in pathogenesis of UCS .
23896716
2013
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Uterine Carcinosarcoma
0.010
AlteredExpression
BEFREE
AKT, EGFR , C-ErbB-2, and C-kit expression in uterine carcinosarcoma .
23896716
2013
×
Entrez Id:
332
Gene Symbol:
BIRC5
BIRC5
Uterine Carcinosarcoma
0.010
AlteredExpression
BEFREE
BIRC5 and hTERT, markers of tumor survival, were up-regulated in CS as compared with normal counterparts.
23932095
2013
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Uterine Carcinosarcoma
0.120
GeneticVariation
BEFREE
Molecular alterations of PIK3CA in uterine carcinosarcoma , clear cell, and serous tumors.
25078343
2014
×
Entrez Id:
23405
Gene Symbol:
DICER1
DICER1
Uterine Carcinosarcoma
0.010
GeneticVariation
BEFREE
DICER1 hotspot mutations were also identified in a single cervical rhabdomyosarcoma and in the rhabdomyosarcomatous component of a uterine carcinosarcoma .
26428316
2015
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
Uterine Carcinosarcoma
0.140
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Uterine Carcinosarcoma
0.120
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Uterine Carcinosarcoma
0.120
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5426
Gene Symbol:
POLE
POLE
Uterine Carcinosarcoma
0.110
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
55294
Gene Symbol:
FBXW7
FBXW7
Uterine Carcinosarcoma
0.110
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5295
Gene Symbol:
PIK3R1
PIK3R1
Uterine Carcinosarcoma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5518
Gene Symbol:
PPP2R1A
PPP2R1A
Uterine Carcinosarcoma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
2263
Gene Symbol:
FGFR2
FGFR2
Uterine Carcinosarcoma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
7307
Gene Symbol:
U2AF1
U2AF1
Uterine Carcinosarcoma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
Uterine Carcinosarcoma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016