|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hyper-variable region of the molecule.
|
1280845 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
We characterized HLA-DRB polymorphisms in Greek patients with RA and in control subjects by restriction fragment length polymorphism analysis.
|
1352449 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Genotyping patients with rheumatoid arthritis for both HLA-DRB1 alleles identifies clinical subsets with distinct profiles of disease manifestations.
|
1416553 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
By sequence analysis, performed on 10 patients, we demonstrate that the DRB1*04 genes of RA show no difference from the DRB1*04 sequences previously published.
|
1429034 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Homozygosity for the HLA-DRB1*0401 allele was a characteristic finding for RA patients with major organ involvement.
|
1602009 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Whereas susceptibility to RA is strongly associated with a conserved HLA-DR beta epitope associated with several DRB1 alleles, it is primarily the Dw4 allele which is associated with progression to Felty's syndrome.
|
1685490 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Negative associations were found between RA and DRB1*1501 (DR2/DRw15) (RR = 0.2, P less than 10(-2) and DQB1*0602 (DQw6) (RR = 0.2, P less than 10(-2), 'corrected' P greater than 0.05).
|
1686751 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis.
|
1724805 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Our results in this population indicate that shared epitopes in the third hypervariable region of DRB1 alleles also play a role in susceptibility to RA.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1895259 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
These different MHC associations in different clinical disease subsets show that rheumatoid disease is immunogenetically heterogeneous and suggest that MHC genes outside the DRB1 locus may also influence susceptibility or modify expression of the rheumatoid disease process.
|
1991218 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Substitution of residues in the third hypervariable region of the first domain of DRB1 appeared to correlate with relative risk for RA.
|
2369430 |
1990 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients.
|
2481309 |
1989 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility.
|
2732676 |
1989 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*0405 is related to the development of RA in Taiwan, while DRB1*0403 was a negative risk factor.
|
7473464 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Naturally processed peptides from immunoaffinity-purified HLA-DRB1*0401, -DRB1*0404 (rheumatoid arthritis (RA)-associated), and -DRB1*0402 (non-RA-associated) molecules were analyzed by capillary liquid chromatography and mass spectrometry.
|
7499850 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
To assess the contribution of HLA-DRB1 alleles in determining rheumatoid arthritis (RA) concordance in monozygotic twins.
|
7514412 |
1994 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization.
|
7540691 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
|
7544977 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA is an important genetic factor in RA and risk is thought to be associated with a consensus sequence of amino acids within the third hypervariable region of certain DRB1 alleles.
|
7552063 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
With the exception of an increased frequency of HLA-DRB1*04 alleles in seropositive patients with rheumatoid arthritis (27.3%) compared with controls (13.1%) (P = 0.02), the frequencies of HLA-DRB1 alleles were similar in patients and controls.
|
7598299 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Almost all racial-ethnic groups share the association of RA with the HLA-DRB1-encoded sequence motif QKRAA or QRRAA.
|
7612412 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Analysis of a microsatellite marker adjacent to the transcription element alpha (TEA) in the T cell receptor alpha delta complex indicates that in the cohort carrying neither the DRB1*04 nor the DRB1*01 allele the relative risk to acquire rheumatoid arthritis is increased (> 13) or decreased (< 0.07), depending on the inherited microsatellite allele adjacent to the TEA locus.
|
7633938 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Possession of the HLA-DRB1*0401/*0404 genotype carries a substantially high risk for RA development specifically in its more severe forms.
|
7674226 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Although there was a suggestion of linkage between some TAP polymorphisms and RA, these seem to be dependent on HLA-DRB1*04, since these positive associations disappeared when HLA-DRB1*04 positive RA patients and controls were compared.
|
7728393 |
1995 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods.
|
7763111 |
1995 |