|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients.
|
2481309 |
1989 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility.
|
2732676 |
1989 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Substitution of residues in the third hypervariable region of the first domain of DRB1 appeared to correlate with relative risk for RA.
|
2369430 |
1990 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Our results in this population indicate that shared epitopes in the third hypervariable region of DRB1 alleles also play a role in susceptibility to RA.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1895259 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Whereas susceptibility to RA is strongly associated with a conserved HLA-DR beta epitope associated with several DRB1 alleles, it is primarily the Dw4 allele which is associated with progression to Felty's syndrome.
|
1685490 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
These different MHC associations in different clinical disease subsets show that rheumatoid disease is immunogenetically heterogeneous and suggest that MHC genes outside the DRB1 locus may also influence susceptibility or modify expression of the rheumatoid disease process.
|
1991218 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis.
|
1724805 |
1991 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
We characterized HLA-DRB polymorphisms in Greek patients with RA and in control subjects by restriction fragment length polymorphism analysis.
|
1352449 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Homozygosity for the HLA-DRB1*0401 allele was a characteristic finding for RA patients with major organ involvement.
|
1602009 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Genotyping patients with rheumatoid arthritis for both HLA-DRB1 alleles identifies clinical subsets with distinct profiles of disease manifestations.
|
1416553 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Negative associations were found between RA and DRB1*1501 (DR2/DRw15) (RR = 0.2, P less than 10(-2) and DQB1*0602 (DQw6) (RR = 0.2, P less than 10(-2), 'corrected' P greater than 0.05).
|
1686751 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hyper-variable region of the molecule.
|
1280845 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
By sequence analysis, performed on 10 patients, we demonstrate that the DRB1*04 genes of RA show no difference from the DRB1*04 sequences previously published.
|
1429034 |
1992 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Several studies have shown that HLA-DRB1 alleles are associated with RA, whereas others have indicated that genes not linked to the HLA complex are also involved.
|
8323379 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
To elucidate the role of HLA-DRB, -DQA, and -DQB genes in patients with rheumatoid arthritis (RA) who developed gold induced nephropathy.
|
8484697 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Seventy-two patients with rheumatoid arthritis (RA) and 82 controls have been typed with the XI Histocompatibility Workshop DRB1 and DQB1 sequence-specific oligonucleotide probes.
|
8362408 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
In this study we have used the polymerase chain reaction (PCR) to compare the level of TCR V beta gene expression by peripheral blood mononuclear cells (PBMC) and by synovial fluid cells obtained from HLA DRB1 *0401 and *0404 RA patients.
|
8513596 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DR2 variants, DRB1*1501 and *1502 are not at reduced frequency in Greek RA patients (DRB1*1501, 14.0% in patients vs. 7.0% in controls; DRB1*1502, 7.0% in patients vs. 7.0% in controls).
|
9098407 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
As in other studies, the frequency of DRB1*0405 in RA patients was significantly higher than in the Japanese controls.
|
8356392 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DR1 and rheumatoid arthritis in Israeli Jews: sequencing reveals that DRB1*0102 is the predominant HLA-DR1 subtype.
|
8456440 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 gene sequences in HLA-DR4 positive and negative patients with rheumatoid arthritis.
|
8494871 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community.
|
8346982 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Investigation of the DQ alleles associated with DR4 showed that the haplotype Dw15-DQ8 (DRB1*0405-DQB1*0302) was a susceptibility factor for RA (RR = 6.36, P < 0.05).
|
8507223 |
1993 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
The model is supported by immunogenetic analysis describing an accumulation of vasculitis patients with rheumatoid arthritis among HLA-DRB1*0401 homozygotes.
|
8060764 |
1994 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Association of TAP2 polymorphism with rheumatoid arthritis is secondary to allelic association with HLA-DRB1.
|
8147927 |
1994 |