|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
(3) Is there an interaction between PTPN22 and the rheumatoid arthritis (RA)-associated HLA-DRB1 shared epitope alleles?
|
15674368 |
2005 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
(All the DRB1*11-positive RA patients had either *04 or *10 allele as their second allele.
|
12021152 |
2002 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
67 Hispanic American patients with RA and a similar number of ethnically matched controls were typed for DRB1 using polymerase chain reaction methods.
|
8856614 |
1996 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Rheumatoid arthritis (RA) is strongly associated with a series of HLA-DRB1 alleles that encode a conserved sequence of amino acids ((70)Q/R K/R R A A(74)) in the DRbeta1 chain, known as the shared epitope (SE).
|
12509632 |
2003 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Rheumatoid arthritis in Singaporean Chinese has previously been shown to be associated with the DRB1*0405, DRB1*1001 haplotypes and to the DRB1*0901 haplotype when the former two were removed.
|
12889993 |
2003 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease.
|
14749714 |
2004 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA) genomic region, most notably with a group of HLA-DRB1 alleles termed the shared epitope (SE).
|
21883133 |
2011 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and associates with HLA-DRB1*04.
|
26844284 |
2015 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs).
|
29033912 |
2017 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
Rheumatoid arthritis (RA) is an autoimmune disease that is strongly associated with the expression of several HLA-DR haplotypes, including DR1 (DRB1*0101).
|
9091584 |
1997 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles were determined in the 92 patients, in 29 DR4 positive rheumatoid arthritis (RA) patients, and in 148 controls from the same geographical area by polymerase chain reaction amplification and oligonucleotide hybridisation.
|
10225816 |
1999 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*08 appears to have a protective influence on RA susceptibility and disease severity in Mexican Americans.
|
10403259 |
1999 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*0101 and *0401 were the most prominently associated subtypes in patients with RA (33.3%, Pcorr = 0.011, and 28.3%, Pcorr = 0.00008, respectively).
|
10405928 |
1999 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*13 allele (the subtype allele of DR6, reported to be protective against the development of RA) was found in 14/119 (12%) of female but in none of the male patients (p=0.036).
|
11247876 |
2001 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*04 alleles in psoriatic arthritis: comparison with rheumatoid arthritis and healthy controls.
|
11704286 |
2001 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 and DQB1 typings were performed in 167 patients with RA in remission, defined according to the American College of Rheumatology criteria.
|
11874840 |
2002 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
DRB1-DQB1-DMB analyses for linkage disequilibrium showed that the DRB1*0401-DQB1*0301 haplotype had the DMB*0103 allele more often than DMB*0101 (estimated haplotype frequencies 0.08 and 0.039 in RA, respectively).
|
11881821 |
2001 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 alleles appear to confer an important bidirectional influence on the risk of disease severity in RA, with 20-fold difference in OR between those associated with the highest (HLA-DRB1*0401) and lowest (HLA-DRB1*1301/02) risk.
|
12136889 |
2002 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
DRB1 associations in seronegative RA patients closely resembled those in controls.
|
12355479 |
2002 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis.
|
12798452 |
2003 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*04 was associated with increased salivary IgG in the RA patients.
|
15124939 |
2004 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection.
|
15288002 |
2004 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA DRB1*01 and DRB1*04 phenotyping does not predict the need for joint surgery in rheumatoid arthritis. A retrospective quantitative evaluation of 300 French patients.
|
15301244 |
2004 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis.
|
15970640 |
2005 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 typing was performed in 408 RA patients from the Leiden Early Arthritis Clinic (the Leiden EAC; a Dutch population-based inception cohort in which disease course was followed up over time), in 423 healthy Dutch controls, and in 720 affected members of 341 US multiplex (sibpair) families of Caucasian origin from the North American RA Consortium (NARAC) with well-established disease and fulfilling the American College of Rheumatology classification criteria for RA.
|
16255021 |
2005 |