|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles are neither necessary nor sufficient to cause the development of RA in a given individual.
|
16309943 |
2005 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*07 and DRB1*15 alleles are thought to be protective or neutral in RA.
|
16331753 |
2005 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 genes and extraarticular rheumatoid arthritis.
|
16542468 |
2006 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 typing classified subjects according to the presence of alleles encoding the RA "shared epitope" (SE) sequence.
|
16887863 |
2006 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis.
|
17086601 |
2006 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis.
|
17266100 |
2007 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*04 gene polymorphisms and expressions profiles of interleukin-18 and interleukin-18 binding protein following in vitro stimulation in human peripheral blood mononuclear cells of healthy individuals and patients with rheumatoid arthritis.
|
17367819 |
2007 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA).
|
17666451 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 SE alleles, however, may significantly contribute to the genetic determination of anti-CCP production in Hungarian patients with RA.
|
17911417 |
2007 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e., HLA-DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304) are associated with protection from RA.
|
18077428 |
2007 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles containing the SE are strongly associated with susceptibility to RA in African Americans.
|
18240241 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 shared epitope (SE) and peptidylarginine deiminase type 4 (PADI4) genotype, both of which have been implicated in anti-CCP generation, are assumed to be associated with RA.
|
18633125 |
2009 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis.
|
18799094 |
2009 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease.
|
20629510 |
2010 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 allele distribution and its relation to rheumatoid arthritis in eastern Black Sea Turkish population.
|
21246357 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles associated with risk of rheumatoid arthritis (RA) encode similar HLA-DRB1 sequences, called the shared epitope (SE).
|
21360493 |
2011 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
DRB1-DERAA alleles showed a protective effect against RA (OR 0.42; P < 0.001).
|
21952999 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 allelic groups were genotyped in 1,073 ACPA-positive RA patients from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study.
|
22307773 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1 SE was associated with reduced, while DR2 serological group (DRB1*15 and *16) with increased, risk for ILD in Japanese patients with RA.
|
22586441 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 genotypes and 36 single nucleotide polymorphisms were tested for association between controls and anti-CCP positive or negative RA.
|
22661644 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1*13 allele alone was found to be protective against to anti-CCP+ and RF- RA (P = 0.0003 and P = 0.006, respectively).
|
23253237 |
2012 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*04 was associated with increased risk for RA and ACPA positivity, while HLA-DRB1*07 was associated with reduced risk for RA and RF synthesis in Algerian patients.
|
24447879 |
2017 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.
|
25524867 |
2014 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*13 is associated with protection from ACPA-positive RA (prevalence 16% vs 28% in ACPA-negative non-RA), but not with significant protection from ACPA in individuals without RA (prevalence: 22%, p value 0.09).
|
26715653 |
2016 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population.
|
27943654 |
2017 |