|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Patients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene.
|
9713901 |
1998 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
We therefore examined the effect of HLA-DRB1*13 on: ACPA presence (systemic autoimmunity associated with RA) in individuals with and without RA, on ACPA characteristics and on clinical outcome measures.
|
26715653 |
2016 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
NCA-LEMS was strongly associated with DRB1*0301 (p<0.0001) and DQB1*0201 (p<0.0001), suggesting that NCA-LEMS is an autoimmune disorder associated with the DR3-DQ2 extended haplotype.
|
10980394 |
2000 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Preliminary results showed increased frequencies of DRB1*11- and DRB*16-associated haplotypes that were found to be protective for autoimmune diseases in some populations.
|
17445222 |
2007 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22.
|
26405068 |
2015 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501.
|
28570922 |
2017 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease.
|
20629510 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
While genome studies map a strong MS susceptibility effect to the region of DRB1*1501, our findings offer a rationale for potential involvement of pathogenic DQ6-associated autoimmunity in MS.
|
22316121 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
PTPN22 appears to be primarily associated with anticitrulline autoimmunity, whereas HLA-DRB1 SE is independently associated with RF.
|
19714585 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Since the DRB1*0301 allele is part of the extended ancestral 8.1 haplotype, it carries with it additional risk factors for autoimmunity, including TNFA*2 and C4A*Q0.
|
10807521 |
2000 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases.
|
24430436 |
2014 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Our results show that there are common risk and protection alleles in both loci, suggesting a core of genetic association with autoimmunity (HLA-DRB1*0301 risk; A9 protection) that could be modulated by other alleles/loci or environmental factors toward one or another disease.
|
14679082 |
2003 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
The development of MS is influenced by environmental factors, particularly the Epstein-Barr virus (EBV), and genetic factors, which include specific HLA types, particularly DRB1*1501-DQA1*0102-DQB1*0602, and a predisposition to autoimmunity in general.
|
17547851 |
2007 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
On the basis of these results, the HLA alleles DRB1*0101 and DRB1*0404 and the PTPN22 R620W variant are consistently associated with autoimmunity in the T1DGC Autoantibody Workshop data.
|
26405072 |
2015 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
DRB1*03:01-DQB1*02:01, the major T1D susceptibility haplotype, was found at a lower frequency in T1D patients with thyroid autoimmunity.
|
29383806 |
2018 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
|
16385499 |
2006 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
It is well known that HLA-DRB1 genotypes have a strong influence on the risk of multifactorial autoimmune diseases, but the effect of CIITA genotypes remains controversial.
|
23777927 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
In Caucasians, we highlighted the definite protective role of HLA-DRB1*14 and DRB1*07 for MS. DRB1*03 is probably the only risk factor for MS besides DRB1*15 and a common genetic foundation for autoimmune disease.
|
21440682 |
2011 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Carriers of pathogenic variants had HLA-DRB1 risk alleles for autoimmune diabetes and clinical characteristics compatible with type 1 diabetes except for the absence of autoimmunity.
|
31365591 |
2019 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Antibodies to citrullinated proteins are associated with HLA 'shared epitope' alleles, and autoimmunity to at least one antigenic sequence, the CEP-1 peptide from citrullinated alpha-enolase (KIHAcitEIFDScitGNPTVE), shows a specific association with HLA-DRB1*0401, *0404, 620W PTPN22, and smoking.
|
20192991 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
The effect of human lymphocyte antigen-DRB1 shared epitope alleles on autoantibody positivity was limited to RA patients who were exposed to Aa These studies identify the periodontal pathogen Aa as a candidate bacterial trigger of autoimmunity in RA.
|
27974664 |
2016 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Multiple autoimmune disorders (e.g.Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease.
|
20631027 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the DRB1*04 alleles and prediabetic islet autoimmunity were generally in the same direction as those with diabetes.
|
14679080 |
2003 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
The INS and the DRB1 loci appear to contribute to the pathogenesis of type 1 diabetes by initiating/modifying insulin-specific autoimmunity.
|
16025255 |
2005 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
In family A, all MS patients and two of five individuals with MS immunopathic trait had HLA DRB1*(15) and in family B, all blood relatives had the rare HLA type DRB1*0103, which is associated with other autoimmune diseases.
|
17262999 |
2006 |