|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma.
|
16005081 |
2005 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease.
|
20629510 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*11 had a significant risk for association with a family history of autoimmunity in autistic children (odds ratio: 5.67; 95% CI: 2.07-16.3).
|
23110937 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*15 is a relevant MS susceptibility locus in the Italian population, possibly with little influence on the occurrence of concomitant autoimmune disorders.
|
23279712 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58).
|
26605347 |
2015 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
DRB1*03:01-DQB1*02:01, the major T1D susceptibility haplotype, was found at a lower frequency in T1D patients with thyroid autoimmunity.
|
29383806 |
2018 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
A gene dosage effect was observed in the associations of DRB1*13:02 with the protection from systemic autoimmune diseases; thus homozygous individuals are more effectively protected from the systemic autoimmune diseases than heterozygotes.
|
27829665 |
2017 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the HLA class II (DRB1) of all the patients was genotyped, including an additional group of patients without the autoimmune disease.
|
26022697 |
2015 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Although HLA-DRB1 and -DQA1 alleles have been associated with adult and juvenile idiopathic inflammatory myopathies (JIIM), they only partially account for the genetic risk for these autoimmune disorders.
|
10886238 |
2000 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Although hepatitis B vaccination given during the neonatal period does not increase autoantibody production in 6-year-old immunized children, we deem useful a more prolonged follow-up for these nonresponder children carrying certain HLA haplotypes (such as C4AQ0,DRB1*0301,DQB1*02), particularly because most autoimmune diseases do not develop until later in life.
|
12093985 |
2002 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
|
23180817 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501.
|
28570922 |
2017 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Antibodies to citrullinated proteins are associated with HLA 'shared epitope' alleles, and autoimmunity to at least one antigenic sequence, the CEP-1 peptide from citrullinated alpha-enolase (KIHAcitEIFDScitGNPTVE), shows a specific association with HLA-DRB1*0401, *0404, 620W PTPN22, and smoking.
|
20192991 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
|
16385499 |
2006 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the DRB1*04 alleles and prediabetic islet autoimmunity were generally in the same direction as those with diabetes.
|
14679080 |
2003 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Besides the acknowledged correlation between the HLA-A*02 and HLA-B*15 alleles (as well as low birth weight) and type I diabetes and between the HLA-B*38 and HLA-DRB1*13 alleles (as well as high birth weight) and several autoimmune diseases, we cannot predict if our babies, healthy at birth, will suffer from these pathologies during life.
|
19500315 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Both generalized and localized vitiligo have the same predisposing major histocompatibility complex alleles, i.e., B*44:03 and DRB1*07:01, in both the populations studied, beside the differences in the frequencies of other alleles, suggesting that localized vitiligo too may be an autoimmune disorder.
|
21833019 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Carriers of pathogenic variants had HLA-DRB1 risk alleles for autoimmune diabetes and clinical characteristics compatible with type 1 diabetes except for the absence of autoimmunity.
|
31365591 |
2019 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Compared with those with low GADA titers, patients with high GADA titers had more prominent traits of insulin deficiency and a profile of more severe autoimmunity resulting in higher A1C, lower BMI, a lower prevalence of metabolic syndrome and its components (P < 0.02 for all), a higher prevalence of IA-2As, TPO antibodies (P < 0.003 for both), and DRB1*03-DQB1*0201 (50 vs. 26.8%, P = 0.001), and a decreasing frequency of DQB1*0602 and DRB1*0403 (from type 2 to low and to high GADA titer autoimmune diabetes; P < 0.001 for trend for both comparisons).
|
17392553 |
2007 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases.
|
24430436 |
2014 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Conversely, native CII autoimmunity was not associated with any specific DRB1 allele.
|
23160643 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity.
|
17728790 |
2007 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
LHGDN |
DRB3*0101 and DRB1*0301 belong to an ancestral haplotype and are associated with many autoimmune diseases linked to antigen presentation, but whereas DR3 is susceptible to type 1 diabetes DR52a is not.
|
17583734 |
2007 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Due to the association with autoimmune diseases and proven application in population genetics, we aimed to investigate alleles of the Class II Human Leukocyte Antigens (HLA-DRB1) in the Mexican Mestizo population with aortic aneurysms and determine possible associations with susceptibility.
|
31174489 |
2019 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
|
20797713 |
2011 |