Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10159
Gene Symbol: ATP6AP2
ATP6AP2
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 Biomarker BEFREE (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis. 31238566

2019

Entrez Id: 767
Gene Symbol: CA8
CA8
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE Colorectal adenomas also showed significant immunopositivity for CA-RP VIII, but its expression level was much lower than in adenocarcinomas. 12950015

2003

Entrez Id: 406994
Gene Symbol: MIR212
MIR212
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE Colorectal adenoma and colorectal cancer have been recently shown to have elevated levels of miR-212. 30021100

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.100 GeneticVariation BEFREE Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. 10197610

1999

Entrez Id: 570
Gene Symbol: BAAT
BAAT
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 Biomarker BEFREE BAT-26 and BAT-40 instability in colorectal adenomas and carcinomas and germline polymorphisms. 10362787

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.200 GeneticVariation BEFREE APC mutations are sufficient for the growth of early colorectal adenomas. 10681434

2000

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.020 AlteredExpression BEFREE MMP-1 was not expressed in any of the 20 cases of colorectal adenoma examined. 11007031

2000

Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.030 GeneticVariation BEFREE Glutathione S-transferase polymorphisms and risk of colorectal adenomas. 11165755

2001

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.020 GeneticVariation BEFREE Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. 11166913

2001

Entrez Id: 4583
Gene Symbol: MUC2
MUC2
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.040 Biomarker BEFREE MUC2 apomucin was localized predominantly in the rough endoplasmic reticulum (RER) in normal colorectal mucosa (n=6), colorectal adenoma (n=8), and colorectal adenocarcinoma (n=10). 11724906

2001

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.040 GeneticVariation BEFREE Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. 12067974

2002

Entrez Id: 2744
Gene Symbol: GLS
GLS
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas. 12408749

2003

Entrez Id: 25825
Gene Symbol: BACE2
BACE2
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 Biomarker BEFREE ALP56 may contribute to colorectal adenoma formation and to an exophytic growth pattern in these adenomas. 12802606

2004

Entrez Id: 83998
Gene Symbol: REG4
REG4
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.020 AlteredExpression BEFREE Reg IV, a differentially expressed gene in colorectal adenoma. 12877807

2003

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.100 GeneticVariation BEFREE K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients. 1341260

1992

Entrez Id: 4548
Gene Symbol: MTR
MTR
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.060 GeneticVariation BEFREE Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk. 14744749

2004

Entrez Id: 10397
Gene Symbol: NDRG1
NDRG1
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE NDRG1 was detected at its protein level by immunohistochemistry (IHC) and image analysis (IA), and NDRG1 mRNA was detected by in situ hybridization (ISH) in formalin-fixed and paraffin-embedded sections with a total of 190 specimens including 38 normal colorectal mucosae, 31 colorectal adenomas, 45 non-metastatic colorectal carcinomas (CRCs), 38 metastatic primary CRC and subsequently regional lymph nodes respectively. 14966915

2004

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.100 GeneticVariation BEFREE PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. 15767339

2005

Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 GeneticVariation BEFREE CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer. 15888281

2005

Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.020 AlteredExpression BEFREE 15-LOX-1 gene expression is significantly reduced in both human colorectal adenomas and carcinomas and associated with decreased survival. 15912043

2005

Entrez Id: 3077
Gene Symbol: HFE
HFE
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 GeneticVariation BEFREE Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. 15956653

2005

Entrez Id: 9770
Gene Symbol: RASSF2
RASSF2
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.020 PosttranslationalModification BEFREE RASSF2 methylation was also frequently identified in colorectal adenomas. 16012945

2005

Entrez Id: 135656
Gene Symbol: MUCL3
MUCL3
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE C6orf37 was a gene up-regulated in colorectal adenoma in our previous study. 16545789

2006

Entrez Id: 55603
Gene Symbol: TENT5A
TENT5A
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 AlteredExpression BEFREE C6orf37 was a gene up-regulated in colorectal adenoma in our previous study. 16545789

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.060 AlteredExpression BEFREE VEGF expression in the colorectal adenoma-carcinoma sequence. 16555551

2006