×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy.
16857985 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
16410449 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient.
16371029 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
16091740 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.
15667533 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
15374878 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia.
15625552 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia.
15863200 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
14604974 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia .
14737077 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
15256420 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
11290608 2001
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
×
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
24404189 2014
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22).
24374719 2014
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
24656771 2014
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial.
24659740 2014
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Minimal residual disease monitoring in t(8;21) acute myeloid leukemia based on RUNX1-RUNX1T1 fusion quantification on genomic DNA.
24616160 2014
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.
24606448 2014
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG).
23115274 2013
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Long term follow up of 93 families with myeloproliferative neoplasms: life expectancy and implications of JAK2V617F in the occurrence of complications.
22818858 2013
×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.
23149070 2013