×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.
23714533 2013
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics.
22571758 2012
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
22147895 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
22829971 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia.
22422826 2012
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.
22744846 2012
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The role of mutations in epigenetic regulators in myeloid malignancies.
22898539 2012
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Cancer stem cells: Tracing clones.
22898540 2012
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Retroviral oncogenes: a historical primer.
22898541 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease.
21689158 2011
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
[Analysis of DNMT3a gene mutations in acute myelogenous leukemia].
21518476 2011
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Impact of genetic features on treatment decisions in AML.
22160010 2011
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.
21765025 2011
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
A case of myeloid sarcoma with correlation to JAK2V617F mutation, complicated by myelofibrosis and secondary acute myeloid leukemia.
22041374 2011
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
DNMT3A mutations in acute myeloid leukemia.
21067377 2010
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications.
20631743 2010
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia.
21120162 2010
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2.
20339092 2010
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.
19357396 2009
×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
19164557 2009
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
10508512 1999
×
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016