Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Therapeutic RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196

2007

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2006

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.390 Therapeutic RGD Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. 14600402

2003

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Therapeutic RGD Our study was designed to investigate whether resveratrol, an agonist of SIRT1, could have favorable effect on osteoporosis and to explore the underlying mechanisms. 25377437

2014

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Biomarker RGD Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. 21550389

2011

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Therapeutic RGD Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. 22555620

2013

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Biomarker RGD Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. 24250662

2013

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Therapeutic RGD Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. 12609558

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.250 Biomarker RGD Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. 22997530

2012

Entrez Id: 2688
Gene Symbol: GH1
GH1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.250 Biomarker RGD Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. 1466160

1992

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.230 Biomarker RGD Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats. 19590507

2009

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.220 Biomarker RGD Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. 22820932

2013

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.220 Biomarker RGD High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. 22036861

2011

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD When compared with the osteoporosis group (p < 0.05), alendronate (30 days), EGb1 and EGb2 (20/30 days) increased the Bcl-2 expression; EGb2 and alendronate (20 days) EGb1 and EGb2 (30 days) reduced the Bax expression; and EGb1 and EGb2 (20/30 days) reduced the X-ray density. 22648569

2013

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Biomarker RGD Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. 19424739

2009

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD These results demonstrate that short-term administration of the IGF-II/IGFBP-2 complex can prevent loss of BMD associated with disuse osteoporosis and stimulate bone formation in adult rats. 12162999

2002

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196

2007

Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor. 18442314

2008

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD The effect of the Ginkgo biloba extract in the expression of Bax, Bcl-2 and bone mineral content of Wistar rats with glucocorticoid-induced osteoporosis. 22648569

2013

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Biomarker RGD Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. 22704852

2012

Entrez Id: 5111
Gene Symbol: PCNA
PCNA
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Biomarker RGD Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats. 22550338

2012

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.200 Biomarker RGD Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. 22820932

2013

Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.200 Therapeutic RGD Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. 16442794

2006

Entrez Id: 1834
Gene Symbol: DSPP
DSPP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.200 Biomarker RGD Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors. 23974864

2014

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Biomarker HPO