×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Four carriers of pathogenic mutations in both BRCA1 and BRCA2 were identified among women who underwent genetic counseling for hereditary susceptibility to breast and ovarian carcinoma at three different Italian institutions.
20373018
2010
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
This study suggests that BRCA1 protein is a prognostic marker in sporadic OC patients with minimal RD.
21368065
2011
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma .
22193042
2012
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
We found that high-grade serous ovarian carcinoma had significantly higher MIR182 (P=0.0003) and HMGA2 (P=0.04) expression, and significantly lower BRCA1 (P<0.0001) and FOXO3 (P<0.001) expression than normal controls.
22790015
2012
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma .
23339184
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma .
23232854
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
The germline BRCA1 mutation rate in USC subjects of 2% is higher than expected in a nonfounder population, suggesting that USC is associated with hereditary breast and ovarian carcinoma in a small proportion of cases.
22811390
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
PosttranslationalModification
BEFREE
BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma --an Indian study.
24385383
2014
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Eligible patients are premenopausal BRCA1 /2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma .
26286255
2015
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
A high proportion of young women with invasive OC have mutations in BRCA1 , and a smaller fraction have mutations in other known OC genes.
26718727
2016
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
28882436
2017
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
With the recent introduction of Poly(ADP-ribose) polymerase inhibitors, a promising novel therapy has become available for ovarian carcinoma (OC ) patients with inactivating BRCA1 or BRCA2 mutations in their tumor.
27767231
2017
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1 /2 mutation carriers because of their increased risk of ovarian carcinoma .
29315498
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Potent immunogenicity in BRCA1 -mutated patients with high-grade serous ovarian carcinoma .
29855141
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Routine germline BRCA1 and BRCA2 testing in patients with ovarian carcinoma : analysis of the Scottish real-life experience.
29460478
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma .
29233532
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma .
30266954
2018
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma .
31653147
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma .
30446260
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 /2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma .
30606148
2019