|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
In the logistic regression models evaluating the association between HLA alleles and chronic sarcoidosis adjusted for rs1049550 and rs2076530, only DRB1*03 was significantly associated with disease resolution.
|
27662826 |
2018 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
The significantly increased frequency of the DR8 (DRB1*08) haplotype, which lacks the DRB3 gene encoding DR52 antigen, suggested that the DR5 (DRB1*11), DR6 (DRB1*14) and DR8 (DRB1*08) of the DRB1 alleles may determine the susceptibility to sarcoidosis among the Japanese.
|
8739505 |
1996 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis.
|
17170388 |
2007 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Further, multivariate logistic regression analysis revealed that the presence of DRB1*11(odds ratio [OR] 9) and DRB1*14 (OR 7), and absence of DRB1*07 (OR 63 and DQB1*0201(OR 3) alleles, were independent predictors of sarcoidosis.
|
12600814 |
2003 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Our results indicate that HLA-DQB1 and not HLA-DRB1 plays an important role in sarcoidosis susceptibility in African Americans.
|
12554629 |
2003 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Susceptibility to the development of sarcoidosis has been demonstrated to be associated with HLA-DR5, -DR6, and -DR8 encoded by the DRB1 gene.
|
7742275 |
1995 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
The data suggest that the LTAlpha and HLA-DRB1 genes themselves or a gene located nearby contributes to the susceptibility to sarcoidosis and that TNF-308*A, LTA+252*G and HLA-DRB1*03 alleles are associated (directly or via linkage with unknown causative locus) with LS as a specific manifestation of the disease.
|
15713215 |
2005 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
CTD_human |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
LHGDN |
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS).
|
15019280 |
2004 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Our results support the importance of HLA-DRB1 as a predisposing gene for sarcoidosis.
|
22074998 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis.
|
30009963 |
2018 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Among the patients with secondary EN, the patient subgroup with sarcoidosis exhibited a significantly increased frequency of HLA-DRB1* 13 compared with healthy controls.
|
11764214 |
2001 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
HLA-DRB1*04 seems to protect against overall sarcoidosis but appears to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS.
|
21565911 |
2011 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Results of in silico binding analyses showed that DRB1*03:01 consistently demonstrated the highest binding affinities for six bacterial peptides previously found in sarcoidosis granulomas, whereas *12:01 displayed the lowest binding affinities.
|
25506722 |
2015 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
ESAT-6 and katG presented by antigen-presenting cells expressing DRB1*1101-induced Th-1 responses from sarcoidosis T cells, thus providing a mechanistic insight for the association of HLA DRB1*1101 with sarcoidosis, and sarcoidosis T cell interaction with microbial antigens.
|
19536643 |
2010 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
In addition, HLA DRB1*1101 and insecticide exposure at work was associated with extrapulmonary sarcoidosis, specifically cardiac sarcoidosis and hypercalcemia (p<0.05) and HLA DRB1*1101 and exposure to molds and musty odors was associated with pulmonary only sarcoidosis (P < 0.05).
|
19382531 |
2008 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
In the group of patients with chronic sarcoidosis DRB1*11 (P=0.0219; OR=2.44), DRB1*15 (P=0.0414; OR=2.47) demonstrated statistically significant difference in comparison to controls only, while a lower frequency of DRB1*13 (P=0.0156; OR=0.24) in this group was statistically significant when compared to both patients with acute sarcoidosis and controls.
|
21796887 |
2011 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
HLA-DRB3*0101 as well as DRB1*0301 positive sarcoidosis patients may have the capacity to present specific sarcoidosis associated antigens in such a way that AV2S3+ CD4+ T cells are stimulated preferentially, generating lung restricted AV2S3+ T cell expansions.
|
11923555 |
2002 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
According to multivariate analysis (MVA), the presence of HLA DRB1*15 was indicated as an independent risk factor for sarcoidosis (OR:2.37; 95% CI: 1.31-4.30, p=0.004).
|
25078644 |
2014 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease.
|
9062964 |
1997 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
|
15019280 |
2004 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Mechanistic studies of putative sarcoid antigens lend further credence to a role of HLA-DRB1 in disease pathogenesis.
|
26164297 |
2015 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Finally, multivariate analysis revealed that the CCR2 association was independent of HLA-DRB1*0301 in both Spanish (P = 0.02 vs. controls) and Swedish cohorts (P = 0.002 vs. non-Löfgren sarcoidosis, P = 0.001 vs. controls).
|
18513341 |
2008 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.
|
11169267 |
2001 |