|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis.
|
30585624 |
2019 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis.
|
30009963 |
2018 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Together, these studies reveal the presence of linked <i>in situ</i> recognition of vimentin by both T- and B-cells in HLA-DRB1*03<sup>+</sup> sarcoidosis patients, associated with a selective humoral immune response to the vimentin C-terminus.
|
30038611 |
2018 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
In the logistic regression models evaluating the association between HLA alleles and chronic sarcoidosis adjusted for rs1049550 and rs2076530, only DRB1*03 was significantly associated with disease resolution.
|
27662826 |
2018 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis.
|
29229112 |
2017 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Results of in silico binding analyses showed that DRB1*03:01 consistently demonstrated the highest binding affinities for six bacterial peptides previously found in sarcoidosis granulomas, whereas *12:01 displayed the lowest binding affinities.
|
25506722 |
2015 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Mechanistic studies of putative sarcoid antigens lend further credence to a role of HLA-DRB1 in disease pathogenesis.
|
26164297 |
2015 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
The aim of this study was to further investigate associations between HLA-DRB1 alleles and the risk for extra-pulmonary manifestations (EPMs), i.e. engagement of the skin, superficial lymph nodes, eyes, nervous system, kidneys, hypercalcemia, parotid and salivary glands, heart, liver, spleen and bone marrow in Scandinavian sarcoidosis patients.
|
24641503 |
2014 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
According to multivariate analysis (MVA), the presence of HLA DRB1*15 was indicated as an independent risk factor for sarcoidosis (OR:2.37; 95% CI: 1.31-4.30, p=0.004).
|
25078644 |
2014 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients.
|
23911360 |
2013 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Our results support the importance of HLA-DRB1 as a predisposing gene for sarcoidosis.
|
22074998 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Our studies implicated that the HLA-DRB1 allele is a major contributing genetic factor in the development of sarcoidosis in Japan.
|
22991420 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
SusceptibilityMutation |
ORPHANET |
Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.
|
22991420 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03.
|
23017494 |
2012 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
These results support the hypothesis that HLA-A, -B, and -DRB1 polymorphisms may play a role in susceptibility and manifestation of sarcoidosis.
|
21513758 |
2011 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
HLA-DRB1*04 seems to protect against overall sarcoidosis but appears to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS.
|
21565911 |
2011 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
In the group of patients with chronic sarcoidosis DRB1*11 (P=0.0219; OR=2.44), DRB1*15 (P=0.0414; OR=2.47) demonstrated statistically significant difference in comparison to controls only, while a lower frequency of DRB1*13 (P=0.0156; OR=0.24) in this group was statistically significant when compared to both patients with acute sarcoidosis and controls.
|
21796887 |
2011 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele.
|
20685690 |
2010 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients.
|
20187937 |
2010 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
In a retrospective case-control study, TNF-alpha G-308A, TNF-alpha G-238A, lymphotoxin-alpha (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients.
|
20070603 |
2010 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
ESAT-6 and katG presented by antigen-presenting cells expressing DRB1*1101-induced Th-1 responses from sarcoidosis T cells, thus providing a mechanistic insight for the association of HLA DRB1*1101 with sarcoidosis, and sarcoidosis T cell interaction with microbial antigens.
|
19536643 |
2010 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
In addition, HLA DRB1*1101 and insecticide exposure at work was associated with extrapulmonary sarcoidosis, specifically cardiac sarcoidosis and hypercalcemia (p<0.05) and HLA DRB1*1101 and exposure to molds and musty odors was associated with pulmonary only sarcoidosis (P < 0.05).
|
19382531 |
2008 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
BEFREE |
Finally, multivariate analysis revealed that the CCR2 association was independent of HLA-DRB1*0301 in both Spanish (P = 0.02 vs. controls) and Swedish cohorts (P = 0.002 vs. non-Löfgren sarcoidosis, P = 0.001 vs. controls).
|
18513341 |
2008 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |