×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.
28435028 2017
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Thus, targeting IL-6/STAT3 /SOCS3 signaling pathway may become an important treatment strategy of colorectal cancer .
28603075 2017
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
In conclusion, microRNA-375 might function as a tumor-repressive gene to inhibit cell proliferation, mainly through targeting both JAK2/STAT3 and MAP3K8/ERK signaling pathways in colorectal cancer .
28186962 2017
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3 /VEGF signaling pathway in colorectal cancer .
27494878 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
IGF/STAT3 /NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer .
26840943 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
BRG1 targeting STAT3 /VEGFC signaling regulates lymphangiogenesis in colorectal cancer .
27145366 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
27191495 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Thus, our study indicates that the high level of IL-35 in colorectal cancer promotes the production of IL-35 via STAT1 and STAT3 , which suppresses T cell proliferation and may participate in tumor immunotolerance.
27682874 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Taken together, our results suggest that EVO modulates the activity of the p53 signaling pathway to induce apoptosis and downregulate MMP3 expression by inactivating the JAK2/STAT3 pathway through the downregulation of PGI to inhibit migration of HCT-116 human colorectal cancer cells.
26580615 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Our findings indicate that c-MET/STAT3 -dependent upregulation of c-FLIPL expression is an important escape mechanism following MEKi treatment in BRAFMT colorectal cancer .
25813020 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Our study aimed to investigate the role of STAT3 /cyclinD1 pathway in the chemotherapeutic resistance of colorectal cancer .
25617735 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
These findings indicate that CPT may be a potential candidate for the treatment and prevention of colorectal cancer in part by inhibiting the activation of Stat3 .
25912550 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer .
26542452 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
B7‑H3 promotes cell migration and invasion through the Jak2/Stat3 /MMP9 signaling pathway in colorectal cancer .
26151358 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
We searched the available articles reporting the prognostic value of p-STAT3 in patients with cancers of the digestive system, mainly including colorectal cancer , gastric cancer, hepatocellular carcinoma, esophagus cancer and pancreatic cancer.
26024373 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
STAT3 is oncogenic in colorectal cancer ; however, knowledge about IL10 signaling upstream of STAT3 in colorectal cancer is lacking.26130064 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition.
25750173 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
25174402 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.23934972 2014
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review ).
24430672 2014
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer development and progression, and also could have a therapeutic potential by targeting SGPP1, Smad2 and STAT3 for colorectal cancer therapy.
25166914 2014
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer .
24473398 2014
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility.
23416975 2014
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Recently, we reported that HDW can inhibit colorectal cancer growth in vivo and in vitro via suppression of the STAT3 pathway.
23291612 2013
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
We evaluated the association between genetic variation in JAK1 (10 SNPs), JAK2 (9 SNPs), TYK2 (5 SNPs), suppressors of cytokine signaling (SOCS)1 (2 SNPs), SOCS2 (2 SNPs), STAT1 (16 SNPs), STAT2 (2 SNPs), STAT3 (6 SNPs), STAT4 (21 SNPs), STAT5A (2 SNPs), STAT5B (3 SNPs), STAT6 (4 SNPs) with risk of colorectal cancer .
22121102 2013