Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. 24204729

2013

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. 23073328

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature. 22225527

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. 22020549

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer. 21696387

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR The identification and management of hereditary diffuse gastric cancer in a large Jordanian family. 21681551

2011

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Prophylactic total gastrectomy for individuals with germline CDH1 mutation. 20719348

2011

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer. 21424370

2011

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice. 20373070

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. 19965908

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 GeneticVariation CLINVAR Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. 20371349

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 GeneticVariation CLINVAR Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. 19269290

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR E-cadherin mutations and cell motility: a genotype-phenotype correlation. 19268661

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. 19269290

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. 19223545

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications. 18391748

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. 18427545

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Hereditary diffuse gastric cancer: association with lobular breast cancer. 18046629

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 GeneticVariation CLINVAR The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. 18427545

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR A short guide to hereditary diffuse gastric cancer. 19725995

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. 17522512

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer. 17634464

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. 17545690

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. 17221870

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.130 CausalMutation CLINVAR Germline E-cadherin mutations in familial lobular breast cancer. 17660459

2007