|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct 4 expression was significantly higher in poorly differentiated (PDSCC) and basaloid (BSCC) subtypes than the other better differentiated tumor morphology.
|
24870750 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The results demonstrated that the expression levels of OCT4 protein in cancer tissues were significantly elevated compared with those in adjacent non‑cancerous tissues (65.0 vs. 42.5%; P=0.005), which was correlated with tumor differentiation (P=0.008).
|
25017645 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition.
|
24475251 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
We found that both Oct-4 and Nanog expression were significantly associated with tumor pathology and poor prognosis in 126 breast cancer patients.
|
25301732 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Moreover, CD133- and/or Oct3/4-positive cholangiocarcinoma patients had significant associations with tumor histology types, tumor stage, and poor prognoses.
|
23917144 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Cells treated with 5-FU also exhibited tumorigenic potential, based on tumor formation assays in nude mice, and Oct3/4-positive cell aggregates were identified in the resulting tumors.
|
23216104 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In xenograft tumors, co-treatment with 1,25(OH)2D3 and cisplatin resulted in downregulation of OCT4 and simultaneous upregulation of p21 and p73, but did not reduce tumor growth significantly more than cisplatin alone.
|
23098692 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, WT-p53 also suppressed colony formation, tumor sphere formation and expression of CSC markers and stemness factors including CD44, Oct4, c-Myc and Klf4 in PC-3 cells.
|
23404342 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Grp78 knockdown dramatically restrained tumor growth along with the inhibition of stem cell regulatory proteins Oct-4 and Slug.
|
24201869 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Here, we profiled OCT4 protein expression in ovarian epithelial cancer (OEC) with benign cystadenoma, borderline tumor and carcinoma tissues as well as different ovarian cancer cell lines and normal ovarian epithelial cells.
|
23921511 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Therefore, the aim of this study was to investigate the expression of OCT1 and OCT3 in CCA and the corresponding non-neoplastic tumor‑surrounding tissue (TST).
|
23440379 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
PosttranslationalModification |
BEFREE |
Our findings suggest that OCT4 is epigenetically regulated by DNA hypomethylation in primary gliomas, which may provide evidence for the role of DNA methylation in tumor and may present a new direction for developing more powerful strategies to treat glioma in the clinic.
|
23670345 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Our findings suggest that, even in the context of vulnerable MVD status and VEGF expression, overexpression of Oct-4 in tumor tissue represents a prognostic factor in primary NSCLC patients.
|
22300949 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
OCT1 (SLC22A1) and OCT3 (SLC22A3) mRNA expression was measured in primary human HCC and corresponding non neoplastic tumor surrounding tissue (TST) by real time PCR (n = 53).
|
22439694 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Testicular germ cell tumors (TGCT) generally respond well to chemotherapy, but tumors that express low levels of the transcription factor OCT4 are associated with chemoresistance and poor prognosis.
|
23002208 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Re-activation of these pluripotent transcription factors (Nanog, Oct4 and/or Sox2) in association with distinct tumorigenic properties could be found in clones isolated from gynecological tumors using various approaches.
|
22806899 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The effect of miR-145 on tumor suppression in T3A-A3 cells was partly reversed by overexpression of Oct4 both in vitro and in vivo.
|
22378186 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Furthermore, miR-143 and miR-145 suppressed tumor sphere formation and expression of CSC markers and 'stemness' factors including CD133, CD44, Oct4, c-Myc and Klf4 in PC-3 cells.
|
22948942 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The expression of OCT4 enables the tumor to have a higher degree of stemness, which in turn results in a poorer clinical outcome for patients with esophageal squamous cell carcinoma.
|
22363145 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
However, function of Oct4 in tumor cells is unclear.
|
22286766 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
While most medulloblastoma samples expressed CD133 and LIN28, OCT4 expression was found to be more sporadic, with detectable levels occurring in 48% of tumors.
|
21725800 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Therefore, Oct-3/4 might contribute to tumor promoting activity in glioblastomas.
|
21938739 |
2012 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
All cell lines were positive for Oct3/4 and nucleostemin; NSTS-11 cells were also able to form xenograft tumors in mice.
|
22156015 |
2011 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct4, an important transcription factor, is highly expressed in several tumors and promotes the colony-forming ability of cancer cells.
|
21674242 |
2011 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The stem cell-related transcription factor Oct4 regulates tumor proliferation and apoptosis, but its role in tumor migration and invasion is still undefined.
|
21798248 |
2011 |