×
Entrez Id:
246
Gene Symbol:
ALOX15
ALOX15
Nasal Polyps
0.410
GeneticVariation
GWASCAT
Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity.
30643255
2019
×
Entrez Id:
2625
Gene Symbol:
GATA3
GATA3
Nasal Polyps
0.130
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
HLA-DQA1
Nasal Polyps
0.120
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
3106
Gene Symbol:
HLA-B
HLA-B
Nasal Polyps
0.110
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
29785
Gene Symbol:
CYP2S1
CYP2S1
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
MIR3936HG
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
60468
Gene Symbol:
BACH2
BACH2
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
27086
Gene Symbol:
FOXP1
FOXP1
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
8809
Gene Symbol:
IL18R1
IL18R1
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
2879
Gene Symbol:
GPX4
GPX4
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
745
Gene Symbol:
MYRF
MYRF
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
746
Gene Symbol:
TMEM258
TMEM258
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
9173
Gene Symbol:
IL1RL1
IL1RL1
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019
×
Entrez Id:
6583
Gene Symbol:
SLC22A4
SLC22A4
Nasal Polyps
0.100
GeneticVariation
GWASCAT
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
30643255
2019