Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 AlteredExpression BEFREE Daily dietary 10 mg of melatonin supplementation might serve as a viable adjunct to SRP that yielded significantly greater CAL gain and PD reduction and lower salivary TNF-α levels and AIS scores in gCP patients with primary insomnia. 30298556

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 Biomarker BEFREE We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). 31365708

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 AlteredExpression BEFREE Serum and GCF endocan, VEGF-A, and TNF-α levels were significantly higher in patients with CP than in healthy individuals (P <0.001) and decreased after treatment (P <0.03). 27976595

2017

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 GeneticVariation BEFREE This study aimed to investigate whether interleukin-10 single nucleotide polymorphisms at positions -1087(G/A) and -597(C/A) are associated with generalised chronic periodontitis and localised aggressive periodontitis. 22077544

2012

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 GeneticVariation BEFREE Twenty-five individuals with severe generalized chronic periodontitis were genotyped for the -1087 IL-10 gene polymorphism. 21309719

2011

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.030 GeneticVariation BEFREE Within the limitations of sample selection and number, the IL-10 gene polymorphism at position -597 seems to be associated with severe generalized CP. 17335372

2007

Entrez Id: 101060233
Gene Symbol: OPN1MW3
OPN1MW3
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE Fifty-five participants with generalized chronic periodontitis (GCP group, n: 21), with localized chronic periodontitis (LCP group, n: 19) and with gingivitis or healthy (control group, n: 15) subjects were treated and followed up for 6 months. 30187981

2019

Entrez Id: 23588
Gene Symbol: KLHDC2
KLHDC2
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 Biomarker BEFREE Fifty-five participants with generalized chronic periodontitis (GCP group, n: 21), with localized chronic periodontitis (LCP group, n: 19) and with gingivitis or healthy (control group, n: 15) subjects were treated and followed up for 6 months. 30187981

2019

Entrez Id: 5891
Gene Symbol: MOK
MOK
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE RAGE G82S gene polymorphism confers susceptibility to generalized chronic periodontitis in type II diabetic subjects of South Indian Tamilian ethnicity. 31078654

2019

Entrez Id: 728458
Gene Symbol: OPN1MW2
OPN1MW2
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE Fifty-five participants with generalized chronic periodontitis (GCP group, n: 21), with localized chronic periodontitis (LCP group, n: 19) and with gingivitis or healthy (control group, n: 15) subjects were treated and followed up for 6 months. 30187981

2019

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE RAGE G82S gene polymorphism confers susceptibility to generalized chronic periodontitis in type II diabetic subjects of South Indian Tamilian ethnicity. 31078654

2019

Entrez Id: 54751
Gene Symbol: FBLIM1
FBLIM1
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 AlteredExpression BEFREE Daily dietary 10 mg of melatonin supplementation might serve as a viable adjunct to SRP that yielded significantly greater CAL gain and PD reduction and lower salivary TNF-α levels and AIS scores in gCP patients with primary insomnia. 30298556

2019

Entrez Id: 57120
Gene Symbol: GOPC
GOPC
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 AlteredExpression BEFREE Daily dietary 10 mg of melatonin supplementation might serve as a viable adjunct to SRP that yielded significantly greater CAL gain and PD reduction and lower salivary TNF-α levels and AIS scores in gCP patients with primary insomnia. 30298556

2019

Entrez Id: 2804
Gene Symbol: GOLGB1
GOLGB1
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE Fifty-five participants with generalized chronic periodontitis (GCP group, n: 21), with localized chronic periodontitis (LCP group, n: 19) and with gingivitis or healthy (control group, n: 15) subjects were treated and followed up for 6 months. 30187981

2019

Entrez Id: 2652
Gene Symbol: OPN1MW
OPN1MW
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE Fifty-five participants with generalized chronic periodontitis (GCP group, n: 21), with localized chronic periodontitis (LCP group, n: 19) and with gingivitis or healthy (control group, n: 15) subjects were treated and followed up for 6 months. 30187981

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 Biomarker BEFREE We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). 31365708

2019

Entrez Id: 5266
Gene Symbol: PI3
PI3
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 AlteredExpression BEFREE Trappin-2 levels were significantly lower in individuals with CP and GAgP, but not gingivitis, compared with healthy individuals. 28777039

2018

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE The polymorphic expression of IL-1RN (rs419598) gene may be associated with a reduced susceptibility to GAgP and GCP in populations of European descent. 29023524

2017

Entrez Id: 929
Gene Symbol: CD14
CD14
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE The results of the present study suggest that the T allele and the TT genotype of the rs2569190 SNP in the promoter region of the CD14 gene are associated with GCP in a South Indian population of Tamil ethnicity. 28829191

2017

Entrez Id: 5921
Gene Symbol: RASA1
RASA1
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 Biomarker BEFREE A total of 84 patients with generalized aggressive periodontitis (GAP,n:29), generalized chronic periodontitis (GCP, n:25), peri-implantitis (PI,n:14), localized aggressive periodontitis (LAP,n:8) and refractory chronic periodontitis (RP,n:8) were consecutively selected from the archives of the Oral Microbiological Diagnostic Laboratory. 25638399

2015

Entrez Id: 9628
Gene Symbol: RGS6
RGS6
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 Biomarker BEFREE A total of 84 patients with generalized aggressive periodontitis (GAP,n:29), generalized chronic periodontitis (GCP, n:25), peri-implantitis (PI,n:14), localized aggressive periodontitis (LAP,n:8) and refractory chronic periodontitis (RP,n:8) were consecutively selected from the archives of the Oral Microbiological Diagnostic Laboratory. 25638399

2015

Entrez Id: 4317
Gene Symbol: MMP8
MMP8
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 AlteredExpression BEFREE This study examines the efficacy of azithromycin in combination with non-surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (GCF) matrix metalloproteinases-8 (MMP-8) levels over 6 months in patients with severe generalized chronic periodontitis (CP). 22324488

2012

Entrez Id: 339479
Gene Symbol: BRINP3
BRINP3
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 AlteredExpression BEFREE A preliminary study on the FAM5C expression in generalized chronic periodontitis. 22355820

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE Although we found significant differences in the occurrence of periodontal bacteria between patients with CP and healthy controls (from P<0.00001 to P<0.05), no significant association between IFN-γ +874A/T polymorphism and periodontal pathogens was observed in any group. 20932510

2011

Entrez Id: 4322
Gene Symbol: MMP13
MMP13
CUI: C1719498
Disease: Generalized chronic periodontitis
Generalized chronic periodontitis
0.010 GeneticVariation BEFREE These data suggest that the -77A/G and 11A/12A polymorphisms of MMP-13 gene are not associated with susceptibility to severe, generalized CP in a Turkish population. 19453573

2009