Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Therapeutic CTD_human Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). 17556722

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Biomarker CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642

2004

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Therapeutic CTD_human Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. 11820775

2002

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Therapeutic CTD_human Adenoviral delivery of human and viral IL-10 in murine sepsis. 11441115

2001

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Biomarker CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674

1998

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.400 Biomarker CTD_human Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis. 8741040

1996

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.370 Biomarker CTD_human Innate immunity and inflammation in sepsis: mechanisms of suppressed host resistance in mice treated with ethanol in a binge-drinking model. 20624996

2010

Entrez Id: 4049
Gene Symbol: LTA
LTA
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 Biomarker CTD_human Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. 22977509

2011

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker CTD_human Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. 23146691

2013

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker CTD_human Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. 19265175

2009

Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.320 Therapeutic CTD_human Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. 16005988

2005

Entrez Id: 3929
Gene Symbol: LBP
LBP
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.310 Biomarker CTD_human A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.310 Biomarker CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746

2010

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.310 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.310 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005

Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo. 27887929

2017

Entrez Id: 136
Gene Symbol: ADORA2B
ADORA2B
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts. 27757725

2016

Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts. 27757725

2016

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746

2010

Entrez Id: 3579
Gene Symbol: CXCR2
CXCR2
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957

2007

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957

2007

Entrez Id: 1440
Gene Symbol: CSF3
CSF3
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Therapeutic CTD_human Acute colchicine intoxication in a child: a case report. 17505274

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065

2005

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642

2004

Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.300 Biomarker CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642

2004