Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE Concentrations of ALT, and to a lesser degree GGT, increased with age in boys with overweight or obesity. 31617910

2020

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. 31504857

2020

Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE Multivariate analyses demonstrated that overweight or obesity was an independent predictor of ALT testing in young people (ages 18-25) but not in children (ages 10-17) and of abnormal test results in all CYP, irrespective of ALT threshold. 31804018

2020

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 AlteredExpression BEFREE Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial. 30660196

2019

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE Conclusions The significant associations between TSH, adiponectin and blood pressure, observed in children and adolescents from a population-based cohort, are attenuated or absent in children and adolescents with overweight or obesity, suggesting that childhood obesity distorts the healthy interplay between the thyroid axis, thyroid-adipokine interaction and blood pressure. 31714888

2019

Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE There was no association between liver enzymes and FPG either in the underweight group or in the normal weight group; however, a significant correlation was observed in the overweight or obesity group (alanine transaminase (ALT), p<0.01; aspartate aminotransferase (AST), p<0.05). 31630095

2019

Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 AlteredExpression BEFREE In multivariate linear regression analysis, alanine aminotransferase was significantly and positively associated with circulating zonulin levels in adolescents with overweight or obesity (P < 0.01) after controlling for the effect of potential confounding factors. 29544751

2018

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 GeneticVariation BEFREE To analyse the association of two PPARGC1A and ADIPOQ polymorphisms as well as their haplotypes, with the development of aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. 28453464

2017

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 AlteredExpression BEFREE Here we aimed to evaluate the effect of high leptin level in follicular fluid (FF) on the proliferation and apoptosis in granule cells and correlate these findings with poor reproductive outcomes in infertile women with overweight or obesity who underwent IVF treatment. 28561185

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity. 28513060

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 AlteredExpression BEFREE An increased risk of multiple myeloma (MM) has been observed among individuals with low prediagnostic circulating levels of adiponectin, a metabolic hormone that is typically underexpressed among those with overweight or obesity. 28602036

2017

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.040 Biomarker BEFREE Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity. 28513060

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 Biomarker BEFREE A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. 31504857

2020

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 Biomarker BEFREE A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. 31504857

2020

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 GeneticVariation BEFREE We also evaluated the presence of PON1 L55M polymorphism in a group of subjects exposed to tobacco smoke and with overweight or obesity on those parameters. 30618305

2019

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 AlteredExpression BEFREE The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold. 31770397

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 AlteredExpression BEFREE However, in four studies, including 16,837 individuals, CRP levels remained associated with the symptoms of depression even after correction for BMI, suggestion that in the absence of overweight or obesity other sources of peripheral inflammation might contribute to presence of depressive symptoms. 29550676

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 Biomarker BEFREE Serum ferritin, C-reactive protein, and chorioamnionitis had little impact on the ORs associating stillbirth with overweight or obesity. 29609190

2018

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 GeneticVariation BEFREE Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention. 29702041

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 GeneticVariation BEFREE Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity. 25037113

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 GeneticVariation BEFREE The results revealed a significant effect of smoking on BMI, but a lack of significant association between BDNF Val66Met polymorphism and overweight or obesity, and no significant association between BDNF Val66Met and BMI changes over time. 23643991

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.020 GeneticVariation BEFREE There is no solid association of polymorphisms related to MTHFR and ACE genes with non-complicated overweight or obesity among Saudi subjects from Qassim Region. 19893205

2009

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.010 Biomarker BEFREE A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. 31504857

2020

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.010 Biomarker BEFREE A Carbohydrate Beverage Reduces Monocytes Expressing TLR4 in Children with Overweight or Obesity. 31825075

2020

Entrez Id: 5023
Gene Symbol: P2RX1
P2RX1
CUI: C4237343
Disease: Overweight or obesity
Overweight or obesity
0.010 AlteredExpression BEFREE However, the simultaneous expression of P2X1, 4 and 7 during overweight or obesity have not been described. 31279218

2019