|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation |
BEFREE |
Methylation of blood-derived DNA was found to be elevated across 17 consecutive marks in the BRCA1 promoter region and decreased at several other genomic regions (including TWIST2 and CTBP1) for 7 women (23%) diagnosed with BRCA1-like breast cancer compared with women in the other groups.
|
30423315 |
2018 |
|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
PosttranslationalModification |
BEFREE |
None of the studied BC cell lines presented hypermethylation of the BRCA1 promoter region.
|
29259228 |
2017 |
|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation |
BEFREE |
In addition to the BRCA1 promoter region, this work identified regions with variable methylation at multiple breast cancer susceptibility genes including PALB2 and MLH1.
|
27902704 |
2016 |
|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
PosttranslationalModification |
BEFREE |
For the index cases, a standardised tumour morphology review had been conducted for all; estrogen (ER) and progesterone receptor (PR) status was available for 401 (89%), and 77 (17%) had a high-risk mutation in a breast cancer susceptibility gene or methylation of the BRCA1 promoter region in peripheral blood DNA.
|
22929433 |
2012 |
|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
Biomarker |
BEFREE |
We hypothesized that constitutional methylation of the BRCA1 promoter region could give rise to such breast cancers in women.
|
20978112 |
2011 |
|
LOC111589215
|
Malignant neoplasm of breast
|
0.060 |
PosttranslationalModification |
BEFREE |
Of 32 sporadic breast cancers investigated in this study, 10 (31%) revealed DNA methylation of the BRCA1 promoter region.
|
10835497 |
2000 |
|
LOC111589215
|
Breast Carcinoma
|
0.040 |
GeneticVariation |
BEFREE |
Methylation of blood-derived DNA was found to be elevated across 17 consecutive marks in the BRCA1 promoter region and decreased at several other genomic regions (including TWIST2 and CTBP1) for 7 women (23%) diagnosed with BRCA1-like breast cancer compared with women in the other groups.
|
30423315 |
2018 |
|
LOC111589215
|
Breast Carcinoma
|
0.040 |
PosttranslationalModification |
BEFREE |
None of the studied BC cell lines presented hypermethylation of the BRCA1 promoter region.
|
29259228 |
2017 |
|
LOC111589215
|
Breast Carcinoma
|
0.040 |
GeneticVariation |
BEFREE |
In addition to the BRCA1 promoter region, this work identified regions with variable methylation at multiple breast cancer susceptibility genes including PALB2 and MLH1.
|
27902704 |
2016 |
|
LOC111589215
|
Breast Carcinoma
|
0.040 |
PosttranslationalModification |
BEFREE |
For the index cases, a standardised tumour morphology review had been conducted for all; estrogen (ER) and progesterone receptor (PR) status was available for 401 (89%), and 77 (17%) had a high-risk mutation in a breast cancer susceptibility gene or methylation of the BRCA1 promoter region in peripheral blood DNA.
|
22929433 |
2012 |
|
LOC111589215
|
Malignant neoplasm of ovary
|
0.030 |
PosttranslationalModification |
BEFREE |
BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.
|
11034065 |
2000 |
|
LOC111589215
|
Malignant neoplasm of ovary
|
0.030 |
PosttranslationalModification |
BEFREE |
The restriction of BRCA1 promoter region hypermethylation to breast and ovarian cancer is consistent with a pathogenetic role of BRCA1 promoter methylation in these tumours.
|
10657950 |
2000 |
|
LOC111589215
|
Carcinoma, Ovarian Epithelial
|
0.030 |
PosttranslationalModification |
BEFREE |
BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.
|
11034065 |
2000 |
|
LOC111589215
|
Carcinoma, Ovarian Epithelial
|
0.030 |
PosttranslationalModification |
BEFREE |
The restriction of BRCA1 promoter region hypermethylation to breast and ovarian cancer is consistent with a pathogenetic role of BRCA1 promoter methylation in these tumours.
|
10657950 |
2000 |
|
LOC111589215
|
Malignant neoplasm of ovary
|
0.030 |
GeneticVariation |
BEFREE |
Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics.
|
10208417 |
1999 |
|
LOC111589215
|
Carcinoma, Ovarian Epithelial
|
0.030 |
GeneticVariation |
BEFREE |
Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics.
|
10208417 |
1999 |
|
LOC111589215
|
ovarian neoplasm
|
0.020 |
PosttranslationalModification |
BEFREE |
The restriction of BRCA1 promoter region hypermethylation to breast and ovarian cancer is consistent with a pathogenetic role of BRCA1 promoter methylation in these tumours.
|
10657950 |
2000 |
|
LOC111589215
|
ovarian neoplasm
|
0.020 |
GeneticVariation |
BEFREE |
Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics.
|
10208417 |
1999 |
|
LOC111589215
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed wild-type (WT) and four sequence variants of the BRCA1 promoter region-found in patients selected for hereditary breast and ovarian cancer syndrome-in respect to their influence on transcription and translation efficiencies in transient transfection assays in the presence or absence of estrogen.
|
24293149 |
2014 |
|
LOC111589215
|
Early-Stage Breast Carcinoma
|
0.010 |
PosttranslationalModification |
BEFREE |
Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer.
|
23405268 |
2013 |
|
LOC111589215
|
Malignant neoplasm of stomach
|
0.010 |
PosttranslationalModification |
BEFREE |
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis.
|
19399343 |
2008 |
|
LOC111589215
|
Carcinogenesis
|
0.010 |
PosttranslationalModification |
BEFREE |
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis.
|
19399343 |
2008 |
|
LOC111589215
|
Stomach Carcinoma
|
0.010 |
PosttranslationalModification |
BEFREE |
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis.
|
19399343 |
2008 |
|
LOC111589215
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker |
BEFREE |
We found a high frequency of hypermethylation of the BRCA1 promoter region in AML (51/133 samples, 38%), in particular in patients with karyotypic aberrations (P=0.026), and in t-AML, as compared to de novo AML (76 vs 31%, P=0.0002).
|
17047656 |
2006 |
|
LOC111589215
|
Ovarian Carcinoma
|
0.010 |
PosttranslationalModification |
BEFREE |
BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.
|
11034065 |
2000 |