Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker GENOMICS_ENGLAND A novel APOA1 mutation in a patient with renal amyloidosis: unveiling amyloid by next-generation sequencing. 31482740

2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker GENOMICS_ENGLAND A case report of hereditary apolipoprotein A-I amyloidosis associated with a novel APOA1 mutation and variable phenotype. 27240838

2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker GENOMICS_ENGLAND Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes. 27604308

2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker CTD_human Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine beta-synthase and apolipoprotein A-I. 18224302

2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker GENOMICS_ENGLAND Organ transplantation in hereditary apolipoprotein AI amyloidosis. 16925563

2006
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 GeneticVariation UNIPROT Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26. 8208902

1994
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 GeneticVariation UNIPROT Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. 1502149

1992
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 GeneticVariation UNIPROT A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy. 2123470

1990
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 GeneticVariation UNIPROT Variant apolipoprotein AI as a major constituent of a human hereditary amyloid. 3142462

1988
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker CTD_human

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0268389
Disease: Amyloidosis, familial visceral
Amyloidosis, familial visceral 		0.700 Biomarker GENOMICS_ENGLAND

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C1704429
Disease: Hypoalphalipoproteinemia, Familial
Hypoalphalipoproteinemia, Familial 		0.560 Biomarker GENOMICS_ENGLAND Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes. 27604308

2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C1704429
Disease: Hypoalphalipoproteinemia, Familial
Hypoalphalipoproteinemia, Familial 		0.560 GermlineCausalMutation ORPHANET Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia. 8282791

1994
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C1704429
Disease: Hypoalphalipoproteinemia, Familial
Hypoalphalipoproteinemia, Familial 		0.560 GermlineCausalMutation ORPHANET The data suggest that a part of familial hypoalphalipoproteinemia might be an autosomal dominant trait due to a completely defective apolipoprotein A-I gene. 8240372

1993
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.400 Biomarker CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400

2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 Biomarker CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400

2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker CTD_human Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS. 21472284

2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0013604
Disease: Edema
Edema 		0.400 Therapeutic CTD_human Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. 20972769

2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.380 Biomarker CTD_human Genomics and the efficacy of aspirin in the treatment of cerebrovascular disease. 19433014

2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.360 Biomarker GENOMICS_ENGLAND

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. 16099942

2005
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.320 Biomarker CTD_human Small dense LDL and atherogenic lipid profile in HIV-positive adults: influence of lopinavir/ritonavir-containing regimen. 12646808

2003
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.310 Therapeutic CTD_human Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. 20972769

2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker CTD_human Notably, expression of alpha-2-macroglobulin, transthyretin, alpha-1-antitrypsin, and properdin was in common in different lung tumor models, but regulation of orosomucoid-8, apolipoprotein-A1, apolipoprotein-C3, apolipoprotein-E, glutathione peroxidase-3, plasma retinol-binding protein, and serum amyloid P component was unique when the serum proteomes of c-myc and c-raf tumor bearing mice were compared. 19180532

2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker CTD_human A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice. 19180532

2009