Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 Biomarker GENOMICS_ENGLAND IGF-I deficiency is transmitted as an autosomal recessive trait and is caused by homozygous mutations in the IGF1 gene. 21396584

2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 Biomarker GENOMICS_ENGLAND A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency. 14684690

2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 GermlineCausalMutation ORPHANET A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency. 14684690

2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 GermlineCausalMutation ORPHANET Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. 8857020

1996
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 Biomarker GENOMICS_ENGLAND Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. 8857020

1996
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1837475
Disease: Insulin-Like Growth Factor I Deficiency
Insulin-Like Growth Factor I Deficiency 		0.800 Biomarker CTD_human

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population. 24586243

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human A custom rat and baboon hypertension gene array to compare experimental models. 22228705

2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human A custom rat and baboon hypertension gene array to compare experimental models. 22228705

2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension. 19502719

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension. 19502719

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study. 19208208

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Biomarker CTD_human Here, we showed that IGF-1 is a potent stimulant of the migration of ER-negative human breast-cancer cells. 18398872

2008
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Biomarker CTD_human IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. 17520698

2007
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Insulin-like growth factor-I promotes migration in human androgen-independent prostate cancer cells via the alphavbeta3 integrin and PI3-K/Akt signaling. 16465378

2006
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.550 Biomarker CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533

2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.510 Therapeutic CTD_human Insulin-like growth factor-I enhances choleretic action of FK506 in rats. 12826230

2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Reducing blood glucose levels in TIDM mice with an orally administered extract of sericin from hIGF-I-transgenic silkworm cocoons. 24632065

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human The exogenous administration of Insulin-like Growth Factor-I (IGF-I) induces hepatoprotective and antifibrogenic actions in experimental liver cirrhosis. 15745444

2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 15591519

2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0005944
Disease: Metabolic Bone Disorder
Metabolic Bone Disorder 		0.500 Therapeutic CTD_human Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrhosis. 11014614

2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.500 Biomarker CTD_human Effect of antenatal glucocorticoid administration on insulin-like growth factor I and II levels in hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia in rats. 10370016

1999
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.480 Therapeutic CTD_human Advanced liver cirrhosis is associated with osteopenia and also with low serum levels of IGF-I. 11014614

2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560

2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker PSYGENET In vivo, the ablation of Casp6 results in a partial rescue of body weight gain, normalized IGF-1 levels, a reversal of the depression-like phenotype and decreased HTT levels. 25583186

2015