Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.560 GermlineCausalMutation ORPHANET Given that residual p105 and p50—translated from the non-mutated alleles—were normal, and altered p50 proteins were absent, we conclude that the CVID phenotype in these families is caused by NF-κB1 p50 haploinsufficiency. 26279205

2015
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.560 Biomarker CTD_human

Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.420 Biomarker CTD_human Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. 21399635

2011
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C4225277
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 12
IMMUNODEFICIENCY, COMMON VARIABLE, 12 		0.400 Biomarker GENOMICS_ENGLAND Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans. 29477724

2018
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C1846546
Disease: Recurrent sinopulmonary infections
Recurrent sinopulmonary infections 		0.400 Biomarker GENOMICS_ENGLAND Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. 26279205

2015
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C4225277
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 12
IMMUNODEFICIENCY, COMMON VARIABLE, 12 		0.400 Biomarker GENOMICS_ENGLAND Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. 26279205

2015
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.370 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.370 Biomarker CTD_human Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. 17107852

2006
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.350 Biomarker PSYGENET Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system. 21195164

2011
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.350 Biomarker PSYGENET We found an association between the presence of the deletion allele in NFKB1 polymorphism and ALC in patients with alcohol dependence. 19673747

2009
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.350 Biomarker PSYGENET NF-kappaB regulates many genes relevant to brain function, and its actions can be potentiated by ethanol; thus, NFKB1 is an excellent candidate gene for alcoholism. 18079108

2008
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.350 Biomarker PSYGENET Alterations in expression of p50 homodimer/NF-kappaB regulated genes may contribute to neuroplastic adaptation underlying alcoholism. 17895971

2007
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.340 Therapeutic CTD_human Taken together these data indicate that the p50 NF-kappaB subunit plays a critical protective role in the injured liver by limiting the expression of TNF-alpha and its recruitment of inflammatory cells. 15743782

2005
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 Biomarker CTD_human NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). 20715105

2011
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker CTD_human NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). 20715105

2011
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.330 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia 		0.320 Biomarker CTD_human

Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.310 Biomarker CTD_human Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.300 Biomarker CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200

2018
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200

2018
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Biomarker CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200

2018
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Biomarker CTD_human The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid. 28823542

2017
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Therapeutic CTD_human The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid. 28823542

2017
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.300 Biomarker PSYGENET Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. 22312433

2012