×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
GENOMICS_ENGLAND
This case highlights the importance of early screening for PTEN mutations in cases of hemimegalencephaly not otherwise explained by another disorder, even in the absence of signs of Proteus syndrome or the full manifestations of Bannayan-Riley Ruvalcaba syndrome .
29444762 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Several of the affected genes were known to be associated with aggressive prostate cancer such as loss of PTEN , CDH1, BCAR1 and gain of MYC.
29295717 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
The long tail of oncogenic drivers in prostate cancer.
29610475 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP ).
29335545 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
28319090 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
GeneticVariation
UNIPROT
Discovery and functional characterization of a neomorphic PTEN mutation.
26504226 2015
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
In this study, we investigated the role of SIRT1 in multiple human prostate cancer cell lines and prostate-specific PTEN knockout mouse model using resveratrol.
23248098 2013
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
GENOMICS_ENGLAND
Lifetime cancer risks in individuals with germline PTEN mutations.
22252256 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
22581815 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters.
22610119 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Since these miRNAs target PTEN (phosphatase and tensin homolog deleted on chromosome 10), we performed Western blot to confirm up-regulation of PTEN in PCa cells.
21714127 2011
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells.
21456062 2011
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
CTD_human
Sequencing analysis confirmed the presence of PTEN splice-acceptor site mutation in intron 8 (c.1027-2A>G), a germline mutation which had not been previously reported in CS .
19968660 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.
20729295 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Lhermitte-Duclos disease
1.000
Biomarker
CTD_human
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis.
19968660 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
CTD_human
In adults, PTEN mutations cause Cowden syndrome where, in addition to the macrocephaly, there is a higher risk of tumour development.
19321504 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Thus, ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma.
19396168 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Lhermitte-Duclos disease
1.000
Biomarker
CTD_human
Bannayan-Riley-Ruvalcaba syndrome: a cause of extreme macrocephaly and neurodevelopmental delay.
19321504 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
GeneticVariation
UNIPROT
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
18716620 2008
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.
19081794 2008
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
GENOMICS_ENGLAND
Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly.
17286265 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
CTD_human
Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers.17526800 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Hamartoma Syndrome, Multiple
1.000
Biomarker
CTD_human
Polydactyly has previously been described in two patients with Lhermitte-Duclos disease and CS and is thus likely to be a rare sign of PTEN mutations.
17427195 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Malignant neoplasm of prostate
1.000
Biomarker
CTD_human
Integrative molecular concept modeling of prostate cancer progression.
17173048 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Lhermitte-Duclos disease
1.000
Biomarker
CTD_human
Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers.
17526800 2007