×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hepatitis, Toxic
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hepatitis, Drug-Induced
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Drug-Induced Acute Liver Injury
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Chemical and Drug Induced Liver Injury
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Chemically-Induced Liver Toxicity
0.300
Biomarker
CTD_human
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
25231249
2015
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Cardiomegaly
0.300
Biomarker
CTD_human
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.
19168439
2009
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Cardiac Hypertrophy
0.300
Biomarker
CTD_human
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.
19168439
2009
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
AMYOTROPHIC LATERAL SCLEROSIS 1
0.300
Biomarker
CTD_human
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
11796754
2002
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Amyotrophic Lateral Sclerosis, Sporadic
0.300
Biomarker
CTD_human
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
11796754
2002
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Amyotrophic Lateral Sclerosis, Familial
0.300
Biomarker
CTD_human
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
11796754
2002
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver carcinoma
0.240
AlteredExpression
BEFREE
High Shc1 expression was closely correlated with poor clinical outcomes and early recurrence of HCC . p66Shc expression was also determined in HCC samples and cell lines and found to be increased.
31398350
2019
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver carcinoma
0.240
AlteredExpression
BEFREE
Alterations in HDAC2, SHC1, RAC1 and IGF1R were linked with a poorer outcome for HCC, and alternative splicing of SHC and RAC1 were significantly decreased and increased in HCC , respectively.
31788087
2019
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver carcinoma
0.240
Biomarker
BEFREE
Shc3 interacted with major vault protein, resulting in activation of MEK1/2 and ERK1/2 independently of Shc1 and c-Raf; this interaction consequently induced epithelial-mesenchymal transition and promoted HCC cell proliferation and metastasis.
29330146
2018
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver carcinoma
0.240
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver carcinoma
0.240
AlteredExpression
LHGDN
Among ten HCC cases with the amplicon 1q21-q22 examined, we found a significant gene expression level of JTB, SHC1 , CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues (P< or =0.04).
12586295
2003
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
hypertensive nephropathy
0.200
Biomarker
RGD
p66Shc regulates renal vascular tone in hypertension-induced nephropathy.
27270176
2016
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hepatitis, Chronic
0.200
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hyperlipidemia
0.200
Biomarker
RGD
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
15044008
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hyperlipoproteinemias
0.200
Biomarker
RGD
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
15044008
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Liver neoplasms
0.200
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hepatoblastoma
0.200
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Malignant neoplasm of liver
0.200
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Hepatoblastoma Caused By Somatic Mutation
0.200
Biomarker
RGD
Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.
15375560
2004
×
Entrez Id:
6464
Gene Symbol:
SHC1
SHC1
Inflammatory Bowel Diseases
0.110
GeneticVariation
BEFREE
We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23.
27569725
2016