Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE In southern Brazil, pediatric adrenocortical tumor is a sentinel cancer for detecting families with germline p.R337H mutation in TP53 gene. 28864397

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE We report a 9-month-old male who was diagnosed with an adrenocortical tumor and later found to harbor a novel TP53 c.559 G > C germline variant, resulting in p.Gly187Arg. 30239254

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE Acquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypes. 22589739

2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE The high frequency of TP53 R337H carriers in southern Brazil is responsible for the highest known incidence of childhood adrenocortical tumor (ACT). 22056871

2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE Our findings highlight the clinical and genetic counseling dilemmas that arise when an inherited TP53 mutation is found in a child with ACT without relatives with Li-Fraumeni-component tumors. 20967502

2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE A unique correlation between a single TP53 mutation (R337H) and ACT has been reported in southern Brazilian children. 17427234

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 Biomarker LHGDN Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity. 17289876

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation LHGDN The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients. 16786124

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE An inherited germline mutation in the p53 gene (TP53 R337H) is detected in virtually all children with ACT in this region and accounts for the excess cases observed. 16200634

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 GeneticVariation BEFREE Inheritance of R337H p53 gene mutation in children with sporadic adrenocortical tumor. 15952083

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 Biomarker HPO

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.500 CausalMutation CGI